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Q8YLG0

- CPDA_NOSS1

UniProt

Q8YLG0 - CPDA_NOSS1

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Can also hydrolyze cGMP.1 PublicationUniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.1 PublicationUniRule annotation

Cofactori

Binds 2 metal cations per subunit.1 Publication

Enzyme regulationi

Activated by iron and manganese.1 Publication

Kineticsi

  1. KM=45 µM for cAMP1 Publication

Vmax=4.9 µmol/min/mg enzyme with cAMP as substrate1 Publication

Vmax=4.4 µmol/min/mg enzyme with cGMP as substrate1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Metal cation 1UniRule annotation
Metal bindingi16 – 161Metal cation 1UniRule annotation
Binding sitei16 – 161cAMPUniRule annotation
Metal bindingi56 – 561Metal cation 1UniRule annotation
Metal bindingi56 – 561Metal cation 2UniRule annotation
Binding sitei56 – 561cAMPUniRule annotation
Metal bindingi86 – 861Metal cation 2UniRule annotation
Metal bindingi155 – 1551Metal cation 2UniRule annotation
Metal bindingi194 – 1941Metal cation 2UniRule annotation
Metal bindingi196 – 1961Metal cation 1UniRule annotation
Binding sitei196 – 1961cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 872cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:alr5338
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2662663',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413371Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.alr5338.

Structurei

3D structure databases

ProteinModelPortaliQ8YLG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiTERTLLW.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YLG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEKLPISIA QITDIHLLAS ESQRLQGIST TESFLAVMKR LEELRPELDL
60 70 80 90 100
LLMTGDLSDD GTPESYENLQ HYLNSLQIAT YWLPGNHDCA IAMDKILNLG
110 120 130 140 150
MVSRRKSFQR GNWNFILLNS SVTDCVYGYL SATTLDWLDS ELKMLPNNPT
160 170 180 190 200
LIALHHPPLS VNSAWIDRSC LQNSQELFAV IDRYPQVKLV LFGHIHQEFR
210 220 230 240 250
RQRHNVHYLG SPSTCYQFQS QSTTFAINQE LPGFRLLKLY ADGTWTTKIE
260
RVPYSLPIEP TVTVSY
Length:266
Mass (Da):30,432
Last modified:March 1, 2002 - v1
Checksum:i46B3475509226736
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB77037.1.
PIRiAB2473.
RefSeqiNP_489378.1. NC_003272.1.
WP_010999462.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB77037; BAB77037; BAB77037.
GeneIDi1108942.
KEGGiana:alr5338.
PATRICi22781413. VBINosSp37423_6142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000019 Genomic DNA. Translation: BAB77037.1 .
PIRi AB2473.
RefSeqi NP_489378.1. NC_003272.1.
WP_010999462.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q8YLG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr5338.

Protocols and materials databases

DNASUi 1108942.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB77037 ; BAB77037 ; BAB77037 .
GeneIDi 1108942.
KEGGi ana:alr5338.
PATRICi 22781413. VBINosSp37423_6142.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238351.
KOi K03651.
OMAi TERTLLW.
OrthoDBi EOG6QG8GQ.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.
  2. "Biochemical properties of a cAMP phosphodiesterase in the cyanobacterium Anabaena sp. strain PCC 7120."
    Fujisawa T., Ohmori M.
    Microbes Environ. 20:92-96(2005)
    Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiCPDA_NOSS1
AccessioniPrimary (citable) accession number: Q8YLG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3