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Q8YKG3 (K6PF1_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase 1

EC=2.7.1.11
Alternative name(s):
Phosphofructokinase 1
Phosphohexokinase 1
Gene names
Name:pfkA1
Ordered Locus Names:all7335
Encoded onPlasmid pCC7120alpha
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termAllosteric enzyme
Complete proteome
Plasmid
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593596-phosphofructokinase 1 HAMAP-Rule MF_00339
PRO_0000111929

Regions

Nucleotide binding24 – 285ATP By similarity
Nucleotide binding168 – 1725ATP By similarity
Nucleotide binding185 – 20117ATP By similarity

Sites

Active site1411Proton acceptor By similarity
Metal binding1991Magnesium; via carbonyl oxygen By similarity
Binding site1761Substrate By similarity
Binding site2771Substrate By similarity
Binding site2831Substrate By similarity
Binding site2861Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YKG3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2D2F4851F385EE68

FASTA35938,288
        10         20         30         40         50         60 
MSKSRRIGIL TSGGDCSGLN AVIRAVVHCA SGKGWEVFGI RQATLGLMAR PPQVSKLEID 

        70         80         90        100        110        120 
QVDPLLTSGG TMLGTTNKGD PFAFPMPDGS FCDRSSEIIA GYHQLDLDAL IGIGGDGSLA 

       130        140        150        160        170        180 
ILRRLAQQGA INLVGIPKTI DNDIGITEHA IGFDTAVNIA TEALDRLHFT AASHSRVMIL 

       190        200        210        220        230        240 
EVMGRDAGHI ALAAGIAGGA DVILIPEILY SMDDICYHIK HRQEEGKNYC LIIVSEAVRT 

       250        260        270        280        290        300 
QDGEILTLTN RLGQSRYGGI GEYLADQISD RIGAETRVTV LGHIQRGGIA SPLDRLVASA 

       310        320        330        340        350 
FGVAAVNLIE AAKYDYMVAW QNRQVITVPI EEAIAQYKAV NPEDALVKTA RGLGIYLGE 

« Hide

References

[1]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000020 Genomic DNA. Translation: BAB77093.1.
PIRAG2519.
RefSeqYP_227636.1. NC_003276.1.

3D structure databases

ProteinModelPortalQ8YKG3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.all7335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB77093; BAB77093; BAB77093.
GeneID1109376.
KEGGana:all7335.
PATRIC22782436. VBINosSp37423_6630.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAEGRSNAI.
OrthoDBEOG644ZRM.
ProtClustDBPRK14071.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF1_NOSS1
AccessionPrimary (citable) accession number: Q8YKG3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways