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Q8YKG3

- PFKA1_NOSS1

UniProt

Q8YKG3 - PFKA1_NOSS1

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Protein
ATP-dependent 6-phosphofructokinase 1
Gene
pfkA1, all7335
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP; via amide nitrogen By similarity
Metal bindingi116 – 1161Magnesium; catalytic By similarity
Sitei117 – 1171Important for substrate specificity; cannot use PPi as phosphoryl donor By similarity
Active sitei141 – 1411Proton acceptor By similarity
Binding sitei176 – 1761Substrate; shared with dimeric partner By similarity
Binding sitei236 – 2361Substrate By similarity
Binding sitei277 – 2771Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 792ATP By similarity
Nucleotide bindingi115 – 1184ATP By similarity

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinase 1 (EC:2.7.1.11)
Short name:
ATP-PFK 1
Short name:
Phosphofructokinase 1
Alternative name(s):
Phosphohexokinase 1
Gene namesi
Name:pfkA1
Ordered Locus Names:all7335
Encoded oniPlasmid pCC7120alpha0 Publication
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Plasmid pCC7120alpha

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359ATP-dependent 6-phosphofructokinase 1UniRule annotation
PRO_0000111929Add
BLAST

Interactioni

Subunit structurei

Homodimer or homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi103690.all7335.

Structurei

3D structure databases

ProteinModelPortaliQ8YKG3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1413Substrate binding By similarity
Regioni183 – 1853Substrate binding By similarity
Regioni283 – 2864Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000248869.
KOiK00850.
OMAiVENRYVE.
OrthoDBiEOG644ZRM.

Family and domain databases

HAMAPiMF_01976. Phosphofructokinase_III.
InterProiIPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YKG3-1 [UniParc]FASTAAdd to Basket

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MSKSRRIGIL TSGGDCSGLN AVIRAVVHCA SGKGWEVFGI RQATLGLMAR    50
PPQVSKLEID QVDPLLTSGG TMLGTTNKGD PFAFPMPDGS FCDRSSEIIA 100
GYHQLDLDAL IGIGGDGSLA ILRRLAQQGA INLVGIPKTI DNDIGITEHA 150
IGFDTAVNIA TEALDRLHFT AASHSRVMIL EVMGRDAGHI ALAAGIAGGA 200
DVILIPEILY SMDDICYHIK HRQEEGKNYC LIIVSEAVRT QDGEILTLTN 250
RLGQSRYGGI GEYLADQISD RIGAETRVTV LGHIQRGGIA SPLDRLVASA 300
FGVAAVNLIE AAKYDYMVAW QNRQVITVPI EEAIAQYKAV NPEDALVKTA 350
RGLGIYLGE 359
Length:359
Mass (Da):38,288
Last modified:March 1, 2002 - v1
Checksum:i2D2F4851F385EE68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000020 Genomic DNA. Translation: BAB77093.1.
PIRiAG2519.
RefSeqiWP_010999884.1. NC_003276.1.
YP_227636.1. NC_003276.1.

Genome annotation databases

EnsemblBacteriaiBAB77093; BAB77093; BAB77093.
GeneIDi1109376.
KEGGiana:all7335.
PATRICi22782436. VBINosSp37423_6630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000020 Genomic DNA. Translation: BAB77093.1 .
PIRi AG2519.
RefSeqi WP_010999884.1. NC_003276.1.
YP_227636.1. NC_003276.1.

3D structure databases

ProteinModelPortali Q8YKG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all7335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB77093 ; BAB77093 ; BAB77093 .
GeneIDi 1109376.
KEGGi ana:all7335.
PATRICi 22782436. VBINosSp37423_6630.

Phylogenomic databases

eggNOGi COG0205.
HOGENOMi HOG000248869.
KOi K00850.
OMAi VENRYVE.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .

Family and domain databases

HAMAPi MF_01976. Phosphofructokinase_III.
InterProi IPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPFKA1_NOSS1
AccessioniPrimary (citable) accession number: Q8YKG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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