Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42SubstrateUniRule annotation1
Binding sitei73SubstrateUniRule annotation1
Sitei73Transition state stabilizerUniRule annotation1
Binding sitei148SubstrateUniRule annotation1
Binding sitei203SubstrateUniRule annotation1
Binding sitei318SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:BMEI0001
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001875891 – 341Uroporphyrinogen decarboxylaseAdd BLAST341

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_0187.

Structurei

3D structure databases

ProteinModelPortaliQ8YJT1.
SMRiQ8YJT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 27Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFZ. Bacteria.
COG0407. LUCA.
HOGENOMiHOG000253896.
KOiK01599.
OMAiSWAGQLS.

Family and domain databases

CDDicd00717. URO-D. 1 hit.
HAMAPiMF_00218. URO_D. 1 hit.
InterProiView protein in InterPro
IPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
PfamiView protein in Pfam
PF01208. URO-D. 1 hit.
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiView protein in PROSITE
PS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YJT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKVLKVID GETVFPPPIW MMRQAGRYLP EYRETRKKAG SFLDLCYSPD
60 70 80 90 100
LAVEVTLQPI RRFGFDAAIL FSDILVVPHA LGRDLRFEEG KGPLMTPIDA
110 120 130 140 150
DEIFWLETEG VAKRLEPVYE TVRLVREQLP DETTLLGFCG APWTVATYMI
160 170 180 190 200
AGHGTPDQAP ARLFAYRFPE AFEKLLNDLA DVSAEYLIEQ LGAGADAVQI
210 220 230 240 250
FDSWSGVLDE DCFERFCIRP VARIVQKVRA VYPQARIIGF PKGAGMLYAG
260 270 280 290 300
YREKTGVDML GLDWSVPLSF AALLQEEGAV QGNLDPLRVV AGGNALDEGV
310 320 330 340
DAILERMGQG PLVFNLGHGI TPQAPIENVQ RMIDRVRGGK S
Length:341
Mass (Da):37,788
Last modified:March 1, 2002 - v1
Checksum:i383CA94E1010D3F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51183.1.
PIRiAD3252.
RefSeqiWP_004684534.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL51183; AAL51183; BMEI0001.
GeneIDi29594977.
KEGGibme:BMEI0001.
bmel:DK63_1433.
PATRICifig|224914.52.peg.1508.

Similar proteinsi

Entry informationi

Entry nameiDCUP_BRUME
AccessioniPrimary (citable) accession number: Q8YJT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families