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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 20FADUniRule annotation6
Nucleotide bindingi274 – 288NADUniRule annotationAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:BMEI0007
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

Q8YJS5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170701 – 636tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGAdd BLAST636

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_0181.

Structurei

3D structure databases

ProteinModelPortaliQ8YJS5.
SMRiQ8YJS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201059.
KOiK03495.
OMAiFRPGYAI.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
PANTHERiPTHR11806. PTHR11806. 1 hit.
PTHR11806:SF0. PTHR11806:SF0. 1 hit.
PfamiView protein in Pfam
PF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiView protein in PROSITE
PS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YJS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAEALAFD VIVIGGGHAG CEAASAAARA GARTALVTHR FDTIGVMSCN
60 70 80 90 100
PAIGGLGKGH LVREIDALDG LMGRVADRAG IQFRLLNRRK GPAVRGPRTQ
110 120 130 140 150
ADRKLYRLSM QQMITEQENL TVVEGGAADL VCDGERISGV TLADGRVLKC
160 170 180 190 200
GAVVLTTGTF LNGLIHIGEK RFPAGRMGEK PALGLSERLL SFGFTLGRLK
210 220 230 240 250
TGTPPRLDGR TIDWQSLDMQ SADEEPVPFS LMTDRITTPQ IECGITRTTP
260 270 280 290 300
ETHDIIRANL HRSAMYSGSI EGIGPRYCPS VEDKIVKFGN RDGHQIFLEP
310 320 330 340 350
EGLDDDTVYP NGISTSLPED VQLEILKTIP GLEKAVLLQP GYAIEYDFID
360 370 380 390 400
PRELKRSLET RKVCGLFLAG QINGTTGYEE AGAQGLLAGL NAARRAAGSE
410 420 430 440 450
PVILQRTEAY IGVMVDDLTS RGVSEPYRMF TSRAEFRLSL RADNADQRLT
460 470 480 490 500
PLADEVGILS EERRKRYLTR ETALSHARMV TQSLSITPNL AGYYDLRLNQ
510 520 530 540 550
DGVRRSAYDL LSYPDINLDR LIAIWPELAS IDPVTREALE IEAQYAVYME
560 570 580 590 600
RQQSDIAVME REERLLIPSG LDFDAISGLS NELKQKLKQR KPETIAEAQR
610 620 630
VDGITPAAVA LLIAQIRKFG GRQKLAAETL EGKGAA
Length:636
Mass (Da):69,429
Last modified:May 27, 2002 - v2
Checksum:i850A8AD97C183BCC
GO

Sequence cautioni

Q8YJS5: The sequence AAL51189 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51189.1. Different initiation.
PIRiAB3253.
RefSeqiWP_004684530.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL51189; AAL51189; BMEI0007.
GeneIDi29593495.
KEGGibme:BMEI0007.
bmel:DK63_1425.
PATRICifig|224914.52.peg.1501.

Similar proteinsi

Entry informationi

Entry nameiMNMG_BRUME
AccessioniPrimary (citable) accession number: Q8YJS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: October 25, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families