Q8YJP2 (XERD_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine recombinase xerD

Gene names

Name:	xerD
Ordered Locus Names:	BMEI0040

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP MF_01807
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of xerC and two molecules of xerD By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01807.
Sequence similarities	Belongs to the 'phage' integrase family. XerD subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Tyrosine recombinase xerD HAMAP MF_01807		PRO_0000095376
Sites
	Active site	158	1	By similarity
	Active site	182	1	By similarity
	Active site	254	1	By similarity
	Active site	257	1	By similarity
	Active site	280	1	By similarity
	Active site	289	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YJP2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: B24290F277D9CB33	FASTA	309	34,158
	10 20 30 40 50 60 MTMRASLAIE NFLEMMSAER GAAQNTLESY RRDLEAAAEE LAAKGVNLAE AETGHIRMTL 70 80 90 100 110 120 DTMAAQGFAP TSQARRLSAL RQFFRFLYSE GFRQDDPTGI LYAPKKQKPL PKIMSVENVG 130 140 150 160 170 180 KLLDRAALEA NEAAEPGERI KALRLHALLE TLYATGLRVS ELVGLPVTVA RTDHRFLLVR 190 200 210 220 230 240 GKGSKDRMVP LSRKARDALQ KFLTLRDSLP GSDDNPWLFP AFSESGHLAR QVFARELKGL 250 260 270 280 290 300 AARAGLAASS VSPHVLRHAF ASHLLQNGAD LRTVQQLLGH ADISTTQIYT HVLEERLHKL VSEHHPLAD

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51222.1.
PIR	AC3257.
RefSeq	NP_538958.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YJP2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1195752.
GenomeReviews	Gene locus BMEI0040 in contig AE008917_GR.
KEGG	bme:BMEI0040.
NMPDR	fig|224914.1.peg.40.
PATRIC	17795626. VBIBruMel146950_1086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG727654.
OMA	IWMEREG.
PhylomeDB	Q8YJP2.
ProtClustDB	PRK00283.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0040-MONOMER.
Family and domain databases
HAMAP	MF_01807. Recomb_XerD. [Tree]
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core. IPR002104. Integrase_catalytic. IPR010998. Integrase_Lambda-type_N. IPR023109. Integrase_recombinase_N. IPR004107. Integrase_SAM-like_N. IPR011932. Recomb_XerD. IPR023009. Tyrosine_recombinase_XerC/XerD. [Graphical view]
Gene3D	G3DSA:1.10.150.130. Integrase_recombinase_N. 1 hit. G3DSA:1.10.443.10. Phage_intgr_like. 1 hit.
KO	K04763.
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
SUPFAM	SSF56349. DNA_brk_join_enz. 1 hit. SSF47823. L_intgrse_like_N. 1 hit.
TIGRFAMs	TIGR02225. Recomb_XerD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XERD_BRUME

Accession

Primary (citable) accession number: Q8YJP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program