Protein translocase subunit secA - Brucella melitensis

Contribute

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8YJG2 (SECA_BRUME)

Last modified November 24, 2009. Version 54. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Protein translocase subunit secA

Gene names

Name:	secA
Ordered Locus Names:	BMEI0121

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-secB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.
Cofactor	May bind 1 zinc ion per subunit Potential.
Subunit structure	Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises secA, secYEG and auxiliary proteins secDFyajC and yidC/oxaA By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity.
Sequence similarities	Belongs to the secA family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein import Inferred from electronic annotation. Source: InterPro protein targeting Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

906

Protein translocase subunit secA HAMAP MF_01382

PRO_1000073465

Regions

Nucleotide binding

8

ATP Potential

Sites

Metal binding

1

Zinc Potential

Metal binding

1

Zinc Potential

Metal binding

1

Zinc Potential

Metal binding

1

Zinc Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8YJG2-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 5D608184C7F3DAF4
Show »

906

102,841

        10         20         30         40         50         60 
MVSFGGLARK IFGSSNDRRV KTLRQRAEQI TALEKNYENL TDEQLQAKTA EFRAALAEGK 

        70         80         90        100        110        120 
SLDSLLPDAF ATAREAAKRV LGMRPFDVQL IGGMVLHERG IAEMRTGEGK TLMATLPVYL 

       130        140        150        160        170        180 
NALEGKGVHV VTVNDYLATR DAETMGRLYN FLGLTVGVIK HGLDDDERRA AYACDITYGT 

       190        200        210        220        230        240 
NNELGFDYLR DNMKYERAQM VQRPHNYAIV DEVDSILIDE ARTPLIISGP LEDRSDFYNL 

       250        260        270        280        290        300 
IDTFIPPLAE EDYEVDEKQK TAIFTEVGTE KVEKLLEAAG HLKGESLYDI ENVAVVHHLN 

       310        320        330        340        350        360 
NALRAHKLFQ RDKDYIVRND EIVIIDEFTG RMMPGRRYSE GLHQALEAKE HVTIQPENQT 

       370        380        390        400        410        420 
LASITFQNYF RMYNKLSGMT GTAATEAEEF GNIYGLEVLE IPTNLPVQRI DEDDEVYRTV 

       430        440        450        460        470        480 
EEKYRAIVRD IRASHEKGQP ILVGTTSIEK SEQLAERLRR EGIKGFQVLN ARYHEQEAYI 

       490        500        510        520        530        540 
IAQAGVPGAV TIATNMAGRG TDIQLGGNLE MRVRQELSDV PEGPEREEKI AAIKADIAQL 

       550        560        570        580        590        600 
KEKALAAGGL YVLATERHES RRIDNQLRGR SGRQGDPGRS KFFLSLQDDL MRIFGSDRMD 

       610        620        630        640        650        660 
GMLQKLGLKE DEAIVHPWIN KALEKAQKKV EARNFEIRKN LLKYDDVMND QRKVIFEQRL 

       670        680        690        700        710        720 
EMMDEEDLTE TVAEMRHEVI EDMVILRIPK DAYAEKWDIA GLKQDIASKL NLDLPVEEWA 

       730        740        750        760        770        780 
KEEGIAEEEF ENRIKEAADK AAAEKAERFG PQIMTYVEKS VIMQSLDNLW REHLVNLDHL 

       790        800        810        820        830        840 
RSVVGFRGYA QRDPLNEYKT EAFELFQTML ANLREVVISQ LMRVEIVREA PPEPQLPPMA 

       850        860        870        880        890        900 
GLHIDGATGE NDFDEAIWAE HQHDDRIVPP AQRDPADPRT WGKVSRNEPC PCGSGKKYKH 


CHGAFE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis."
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E.

expand/collapse author list

Overbeek R.
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
	AE008917 Genomic DNA. Translation: AAL51303.1.
PIR	AD3267.
RefSeq	NP_539039.1.
3D structure databases
HSSP	HSSP built from PDB template 1OZB based on UniProtKB P43803.
ModBase	Search...
Genome annotation databases
GeneID	1195833.
GenomeReviews	Gene locus BMEI0121 in contig AE008917_GR.
KEGG	bme:BMEI0121.
NMPDR	fig\|224914.1.peg.121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YJG2.
OMA	LTGRGVH
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0121-MON.
Family and domain databases
HAMAP	MF_01382. [Tree]
InterPro	IPR004027. SEC_C_motif. IPR000185. SecA. IPR011115. SecA_DEAD. IPR014018. SecA_motor_DEAD. IPR011130. SecA_PP_bd. IPR011116. SecA_Wing/Scaffold. [Graphical view]
Gene3D	G3DSA:1.10.3060.10. SecA_SW. 1 hit.
Pfam	PF02810. SEC-C. 1 hit. PF07517. SecA_DEAD. 1 hit. PF01043. SecA_PP_bind. 1 hit. PF07516. SecA_SW. 1 hit. [Graphical view]
PRINTS	PR00906. SECA.
TIGRFAMs	TIGR00963. secA. 1 hit.
PROSITE	PS01312. SECA. 1 hit. PS51196. SECA_MOTOR_DEAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SECA_BRUME

Accession

Primary (citable) accession number: Q8YJG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2002
Last modified:	November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents