Reviewed, UniProtKB/Swiss-Prot Q8YJD9 (XERC_BRUME)

Names and origin

Protein names

Recommended name:
    Tyrosine recombinase xerC

Gene names

Name:	xerC
Ordered Locus Names:	BMEI0147

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity.
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of xerC and two molecules of xerD By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerC subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: HAMAP transposition, DNA-mediated Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW tyrosine-based site-specific recombinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Tyrosine recombinase xerC HAMAP MF_01808		PRO_0000095286
Sites
	Active site	168	1	By similarity
	Active site	193	1	By similarity
	Active site	261	1	By similarity
	Active site	264	1	By similarity
	Active site	287	1	By similarity
	Active site	296	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YJD9-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: C3D6A70583DD692D	FASTA	315	34,066
	10 20 30 40 50 60 MATNSEFLIP ARADLAAARE EWLKSLKTMR RLSDNTLIAY ERDTRQFLQF LTGHLGEPPS 70 80 90 100 110 120 LKEIGNLRIA DLRSFLANRR NDGAGARTLG RGLAGVRSLL RHLEKRGLVN AAGASAMRAP 130 140 150 160 170 180 RQPKSLPKPL TADDARRVVS ADGQMAEEPW IAARNAAVLT LLYGCGLRIS EALGLSGDAL 190 200 210 220 230 240 SDPSARSMTI TGKGSKTRLV PLLPAVHKAV AQYRALCPFD LSAGQLLFRG AKGGPLHAAI 250 260 270 280 290 300 IQREMQKLRA GLGLPDSATP HALRHSFATH LLGRGGDLRT IQELLGHASL STTQVYTGVD 310 TQRLLEVYDK THPRA

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008917 Genomic DNA. Translation: AAL51329.1.
PIR	AF3270.
RefSeq	NP_539065.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1195859.
GenomeReviews	Gene locus BMEI0147 in contig AE008917_GR.
KEGG	bme:BMEI0147.
NMPDR	fig|224914.1.peg.147.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YJD9.
OMA	LEATDVR
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0147-MON.
Family and domain databases
HAMAP	MF_01808. [Tree]
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core_phage. IPR002104. Integrase_cat-core_phage. IPR010998. Integrase_Lambda-type_N. IPR004107. Integrase_SAM-like_N_phage. IPR011931. Recomb_XerC. [Graphical view]
Gene3D	G3DSA:1.10.443.10. Phage_intgr_like. 1 hit.
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02224. recomb_XerC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XERC_BRUME

Accession

Primary (citable) accession number: Q8YJD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	March 1, 2002
Last modified:	November 24, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)