Reviewed, UniProtKB/Swiss-Prot Q8YJB8 (FTSK_BRUME)

Names and origin

Protein names

Recommended name:
    DNA translocase ftsK

Gene names

Name:	ftsK
Ordered Locus Names:	BMEI0168

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	817 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it By similarity.
Subunit structure	Homohexamer. This suggests the formation of a ring between the two cells at the septum that surrounds DNA By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side. Note: Located at the septum. The large C-terminal part of the protein is cytoplasmic Potential.
Sequence similarities	Contains 1 FtsK domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 817	817	DNA translocase ftsK		PRO_0000098243
Regions
	Transmembrane	31 – 53	23	Potential
	Transmembrane	83 – 105	23	Potential
	Transmembrane	118 – 140	23	Potential
	Transmembrane	144 – 166	23	Potential
	Transmembrane	173 – 195	23	Potential
	Domain	452 – 671	220	FtsK
	Nucleotide binding	469 – 476	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YJB8-1 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: 7F94030AACA316DF	FASTA	817	88,806
	10 20 30 40 50 60 MRQGYSPSYP LRDERITEDR LRFANLVRRQ VYILLGLGLL SLTAMAVGAL ATWNVADPSF 70 80 90 100 110 120 SHATDNPVTN ALGYPGAVFS DLAMQFFGLA SVPALLPLAV WSLLLMIRGY IGRIARRSLA 130 140 150 160 170 180 WVGAALLFAA IASCFAVPQS WPMPIGLGGV FGDMLLRIPG FFLGGFPQGA IASAIALVLA 190 200 210 220 230 240 FPALWFCFFA SGIIGRGAEA VNPAMLSANR SADDEFADED ADNEAGGGFH FIGALTHLVL 250 260 270 280 290 300 MTTATIRRMT GLGRRRSRED DFDDMRMVRR SAETRNAPPP RARKARVEQT APSPKPGPRA 310 320 330 340 350 360 QREAQPSFLK DNGIFEMPSL HFLAEPKLVQ RDPALSKDAL EQNARLLAGV LEDFGVRGEI 370 380 390 400 410 420 INVKPGPVVT LYELEPAPGI KSSRVIGLAD DIARSMSAIA ARVAVIPGRN AIGIELPNPK 430 440 450 460 470 480 REMVYLREML ASRDFEQSKA KLALALGKTI NGEPVIADIA KMPHVLVAGT TGSGKSVAIN 490 500 510 520 530 540 TMILSLLYRM TPQECRLIMI DPKMLELSVY DGIPHLLTPV VTDPKKAVVA LKWTVREMED 550 560 570 580 590 600 RYRKMSKVGV RNIDGFNQRV GLAQKKGEPI ARTVQTGFDR NTGEAIYETE ELDLEPMPYI 610 620 630 640 650 660 VVIIDEMADL MMVAGKDIEG AVQRLAQMAR AAGIHVIMAT QRPSVDVITG TIKANFPTRI 670 680 690 700 710 720 SFQVTSKIDS RTILGEQGAE QLLGQGDMLF MAGGGRIQRV HGPFVGDDEV ERIVQHLKLQ 730 740 750 760 770 780 GVPEYLDAIT EDEDDDEGGS GPAGTGNLED SDDPYDQAVA VVLRDKKAST SYIQRRLGIG 790 800 810 YNRAASIIER MEDEGIVGPA NHAGKREILV PTGDDDF

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008917 Genomic DNA. Translation: AAL51350.1. Different initiation.
PIR	AC3273.
RefSeq	NP_539086.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1195880.
GenomeReviews	Gene locus BMEI0168 in contig AE008917_GR.
KEGG	bme:BMEI0168.
NMPDR	fig|224914.1.peg.168.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YJB8.
OMA	SLSHATS
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0168-MON.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR018541. DNA_translocase_Ftsk_gamma. IPR002543. FtsK_SpoIIIE. [Graphical view]
Pfam	PF09397. Ftsk_gamma. 1 hit. PF01580. FtsK_SpoIIIE. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00843. Ftsk_gamma. 1 hit. [Graphical view]
PROSITE	PS50901. FTSK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSK_BRUME

Accession

Primary (citable) accession number: Q8YJB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	August 29, 2003
Last modified:	November 24, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)