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Q8YJB8

- FTSK_BRUME

UniProt

Q8YJB8 - FTSK_BRUME

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (29 Aug 2003)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi472 – 4776ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-171-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Ordered Locus Names:BMEI0168
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817DNA translocase FtsKPRO_0000098243Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi224914.BMEI0168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YJB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini247 – 817571CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini452 – 671220FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000010003.
    KOiK03466.
    OMAiSEDPYDQ.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YJB8-1 [UniParc]FASTAAdd to Basket

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    MRQGYSPSYP LRDERITEDR LRFANLVRRQ VYILLGLGLL SLTAMAVGAL    50
    ATWNVADPSF SHATDNPVTN ALGYPGAVFS DLAMQFFGLA SVPALLPLAV 100
    WSLLLMIRGY IGRIARRSLA WVGAALLFAA IASCFAVPQS WPMPIGLGGV 150
    FGDMLLRIPG FFLGGFPQGA IASAIALVLA FPALWFCFFA SGIIGRGAEA 200
    VNPAMLSANR SADDEFADED ADNEAGGGFH FIGALTHLVL MTTATIRRMT 250
    GLGRRRSRED DFDDMRMVRR SAETRNAPPP RARKARVEQT APSPKPGPRA 300
    QREAQPSFLK DNGIFEMPSL HFLAEPKLVQ RDPALSKDAL EQNARLLAGV 350
    LEDFGVRGEI INVKPGPVVT LYELEPAPGI KSSRVIGLAD DIARSMSAIA 400
    ARVAVIPGRN AIGIELPNPK REMVYLREML ASRDFEQSKA KLALALGKTI 450
    NGEPVIADIA KMPHVLVAGT TGSGKSVAIN TMILSLLYRM TPQECRLIMI 500
    DPKMLELSVY DGIPHLLTPV VTDPKKAVVA LKWTVREMED RYRKMSKVGV 550
    RNIDGFNQRV GLAQKKGEPI ARTVQTGFDR NTGEAIYETE ELDLEPMPYI 600
    VVIIDEMADL MMVAGKDIEG AVQRLAQMAR AAGIHVIMAT QRPSVDVITG 650
    TIKANFPTRI SFQVTSKIDS RTILGEQGAE QLLGQGDMLF MAGGGRIQRV 700
    HGPFVGDDEV ERIVQHLKLQ GVPEYLDAIT EDEDDDEGGS GPAGTGNLED 750
    SDDPYDQAVA VVLRDKKAST SYIQRRLGIG YNRAASIIER MEDEGIVGPA 800
    NHAGKREILV PTGDDDF 817
    Length:817
    Mass (Da):88,806
    Last modified:August 29, 2003 - v2
    Checksum:i7F94030AACA316DF
    GO

    Sequence cautioni

    The sequence AAL51350.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51350.1. Different initiation.
    PIRiAC3273.
    RefSeqiNP_539086.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51350; AAL51350; BMEI0168.
    GeneIDi1195880.
    KEGGibme:BMEI0168.
    PATRICi17850291. VBIBruMel92729_0177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51350.1 . Different initiation.
    PIRi AC3273.
    RefSeqi NP_539086.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YJB8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51350 ; AAL51350 ; BMEI0168 .
    GeneIDi 1195880.
    KEGGi bme:BMEI0168.
    PATRICi 17850291. VBIBruMel92729_0177.

    Phylogenomic databases

    HOGENOMi HOG000010003.
    KOi K03466.
    OMAi SEDPYDQ.
    OrthoDBi EOG6S52GD.

    Enzyme and pathway databases

    BioCyci BMEL224914:GCJ0-171-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiFTSK_BRUME
    AccessioniPrimary (citable) accession number: Q8YJB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: August 29, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3