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Q8YJ95

- RF1_BRUME

UniProt

Q8YJ95 - RF1_BRUME

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Protein
Peptide chain release factor 1
Gene
prfA, BMEI0191
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity.UniRule annotation

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide chain release factor 1
    Short name:
    RF-1
    Gene namesi
    Name:prfA
    Ordered Locus Names:BMEI0191
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Peptide chain release factor 1UniRule annotation
    PRO_0000177644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei235 – 2351N5-methylglutamine By similarity

    Post-translational modificationi

    Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity.UniRule annotation

    Keywords - PTMi

    Methylation

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI0191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YJ95.
    SMRiQ8YJ95. Positions 68-355.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000074815.
    KOiK02835.
    OMAiNDINDRE.
    OrthoDBiEOG6TN48J.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    HAMAPiMF_00093. Rel_fac_1.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view]
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00019. prfA. 1 hit.
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YJ95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIALPQDRMD QLLKRFSMIE SQMANNPDSD TYVKLASEYS ELQDVVGKIR    50
    ELSDARMEAS DLAAMRDDAS TDAEMRALAV EELPEVEKRI AVLEQDVQIL 100
    LLPKDAADDK NAILEIRAGT GGLEAALFAG DLFRMYERYA AEKGWRVELV 150
    SASEGDAGGY KEIIATVSGK GVFSKLKFES GVHRVQRVPE TEAGGRIHTS 200
    AATVAVLPEA EDIDIEIRNE DIRIDTMRAS GAGGQHVNTT DSAVRITHIP 250
    TGIMVVQAEK SQHQNRARAM QILRARLYDM ERQKAESERS QARRSQVGSG 300
    DRSERIRTYN FPQGRVTDHR INLTLYKLDR VMEGELDELV DALISDHQTA 350
    LLAELGEQP 359
    Length:359
    Mass (Da):39,909
    Last modified:April 3, 2002 - v2
    Checksum:i9B447F031AD72D84
    GO

    Sequence cautioni

    The sequence AAL51373.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51373.1. Different initiation.
    PIRiAB3276.
    RefSeqiNP_539109.2. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51373; AAL51373; BMEI0191.
    GeneIDi1195903.
    KEGGibme:BMEI0191.
    PATRICi17850339. VBIBruMel92729_0201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51373.1 . Different initiation.
    PIRi AB3276.
    RefSeqi NP_539109.2. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YJ95.
    SMRi Q8YJ95. Positions 68-355.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51373 ; AAL51373 ; BMEI0191 .
    GeneIDi 1195903.
    KEGGi bme:BMEI0191.
    PATRICi 17850339. VBIBruMel92729_0201.

    Phylogenomic databases

    HOGENOMi HOG000074815.
    KOi K02835.
    OMAi NDINDRE.
    OrthoDBi EOG6TN48J.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    HAMAPi MF_00093. Rel_fac_1.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view ]
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00019. prfA. 1 hit.
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiRF1_BRUME
    AccessioniPrimary (citable) accession number: Q8YJ95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: April 3, 2002
    Last modified: May 14, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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