Q8YJ77 (NADD_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	BMEI0209

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP MF_00244
Catalytic activity	ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. HAMAP MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP MF_00244
Sequence similarities	Belongs to the NadD family.
Sequence caution	The sequence AAL51391.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Probable nicotinate-nucleotide adenylyltransferase HAMAP MF_00244		PRO_0000181395

Sequences

	Sequence		Length	Mass (Da)
	Q8YJ77 [UniParc]. Last modified October 31, 2003. Version 2. Checksum: 9615792D51B51580	FASTA	194	21,977
	10 20 30 40 50 60 MTVGLFGGSF NPPHGGHALV AEIAIRRLKL DQLWWMVTPG NPLKDSRELA PLSERLRLSE 70 80 90 100 110 120 EVAEDPRIKV TALEAAFHVR YTADTLALIR NANPDVYFVW VMGADNLASF HRWQRWREIA 130 140 150 160 170 180 QNFPIAIIDR PGSTLSYLSS RMAQTFSDSR LDERYAPVLA RRMPPAWTFI HGPRSSLSST 190 ALRKVQLKKA PSKK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51391.1. Different initiation.
PIR	AD3278.
RefSeq	NP_539127.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YJ77.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1195921.
GenomeReviews	Gene locus BMEI0209 in contig AE008917_GR.
KEGG	bme:BMEI0209.
PATRIC	17802026. VBIBruMel146950_3330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG739448.
OMA	WMAGRDI.
PhylomeDB	Q8YJ77.
ProtClustDB	PRK00071.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0209-MONOMER.
Family and domain databases
HAMAP	MF_00244. NaMN_adenylyltr. [Tree]
InterPro	IPR004820. Cytidylyltransf. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00969.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_BRUME

Accession

Primary (citable) accession number: Q8YJ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	October 31, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program