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Protein

Protease HtpX homolog

Gene

htpX

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Zinc; catalyticUniRule annotation1
Active sitei131UniRule annotation1
Metal bindingi134Zinc; catalyticUniRule annotation1
Metal bindingi202Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM48.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpX homologUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:BMEI0236
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001388541 – 325Protease HtpX homologAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2911.

Structurei

3D structure databases

ProteinModelPortaliQ8YJ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227301.
KOiK03799.
OMAiNPQGLIS.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX. 1 hit.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YJ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMTKTAMLI ALMTVMFMSI GYLLGGGGGM MIALVIAVAM NLFGYWNSDK
60 70 80 90 100
MVLRMYNAQE VDERSAPEYY RMVSGLAANA GLPMPKVYII HEDQPNAFAT
110 120 130 140 150
GRNPENAAVA ATTGLLNWLS PEEVAGVMAH ELAHVQNRDT LTMTIVATLA
160 170 180 190 200
GAISMLGNFA FFLGGNRENG NGVMGVVGTL LAMIVAPFGA MIVQMAVSRT
210 220 230 240 250
REYAADKRGA EICGNPLWLS SALGKIARGA KVIPNEEAEH NPATAHMFII
260 270 280 290 300
NPLSGRGADN LFSTHPDTDN RIAALEQMAA ETGIRSAAMT ARAAAPSQNS
310 320
GPWGQRSDNA GGNSNGGSRY RGPWS
Length:325
Mass (Da):34,472
Last modified:October 19, 2002 - v2
Checksum:i92F2DBFD8D8B4D13
GO

Sequence cautioni

The sequence AAL51418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51418.1. Different initiation.
PIRiAG3281.
RefSeqiWP_004684282.1. NZ_GG703781.1.

Genome annotation databases

EnsemblBacteriaiAAL51418; AAL51418; BMEI0236.
KEGGibme:BMEI0236.
bmel:DK63_1195.
PATRICi17850470. VBIBruMel92729_0258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51418.1. Different initiation.
PIRiAG3281.
RefSeqiWP_004684282.1. NZ_GG703781.1.

3D structure databases

ProteinModelPortaliQ8YJ50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_2911.

Protein family/group databases

MEROPSiM48.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL51418; AAL51418; BMEI0236.
KEGGibme:BMEI0236.
bmel:DK63_1195.
PATRICi17850470. VBIBruMel92729_0258.

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227301.
KOiK03799.
OMAiNPQGLIS.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX. 1 hit.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTPX_BRUME
AccessioniPrimary (citable) accession number: Q8YJ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.