Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8YJ50

- HTPX_BRUME

UniProt

Q8YJ50 - HTPX_BRUME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protease HtpX homolog

Gene

htpX

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Zinc; catalyticUniRule annotation
Active sitei131 – 1311UniRule annotation
Metal bindingi134 – 1341Zinc; catalyticUniRule annotation
Metal bindingi202 – 2021Zinc; catalyticUniRule annotation

GO - Molecular functioni

  1. metalloendopeptidase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpX homologUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:BMEI0236
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalUniRule annotationAdd
BLAST
Transmembranei145 – 16521HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Protease HtpX homologPRO_0000138854Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI0236.

Structurei

3D structure databases

ProteinModelPortaliQ8YJ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000227301.
KOiK03799.
OMAiETSAPQF.
OrthoDBiEOG6F55J5.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YJ50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMTKTAMLI ALMTVMFMSI GYLLGGGGGM MIALVIAVAM NLFGYWNSDK
60 70 80 90 100
MVLRMYNAQE VDERSAPEYY RMVSGLAANA GLPMPKVYII HEDQPNAFAT
110 120 130 140 150
GRNPENAAVA ATTGLLNWLS PEEVAGVMAH ELAHVQNRDT LTMTIVATLA
160 170 180 190 200
GAISMLGNFA FFLGGNRENG NGVMGVVGTL LAMIVAPFGA MIVQMAVSRT
210 220 230 240 250
REYAADKRGA EICGNPLWLS SALGKIARGA KVIPNEEAEH NPATAHMFII
260 270 280 290 300
NPLSGRGADN LFSTHPDTDN RIAALEQMAA ETGIRSAAMT ARAAAPSQNS
310 320
GPWGQRSDNA GGNSNGGSRY RGPWS
Length:325
Mass (Da):34,472
Last modified:October 19, 2002 - v2
Checksum:i92F2DBFD8D8B4D13
GO

Sequence cautioni

The sequence AAL51418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51418.1. Different initiation.
PIRiAG3281.
RefSeqiNP_539154.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51418; AAL51418; BMEI0236.
GeneIDi1195948.
KEGGibme:BMEI0236.
PATRICi17850470. VBIBruMel92729_0258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51418.1 . Different initiation.
PIRi AG3281.
RefSeqi NP_539154.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YJ50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL51418 ; AAL51418 ; BMEI0236 .
GeneIDi 1195948.
KEGGi bme:BMEI0236.
PATRICi 17850470. VBIBruMel92729_0258.

Phylogenomic databases

HOGENOMi HOG000227301.
KOi K03799.
OMAi ETSAPQF.
OrthoDBi EOG6F55J5.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-247-MONOMER.

Family and domain databases

HAMAPi MF_00188. Pept_M48_protease_HtpX.
InterProi IPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view ]
Pfami PF01435. Peptidase_M48. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiHTPX_BRUME
AccessioniPrimary (citable) accession number: Q8YJ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 26, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3