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Q8YJ50 (HTPX_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protease HtpX homolog

EC=3.4.24.-
Gene names
Name:htpX
Ordered Locus Names:BMEI0236
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00188

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00188.

Sequence similarities

Belongs to the peptidase M48B family.

Sequence caution

The sequence AAL51418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Protease HtpX homolog HAMAP-Rule MF_00188
PRO_0000138854

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane173 – 19321Helical; Potential

Sites

Active site1311 By similarity
Metal binding1301Zinc; catalytic By similarity
Metal binding1341Zinc; catalytic By similarity
Metal binding2021Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YJ50 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: 92F2DBFD8D8B4D13

FASTA32534,472
        10         20         30         40         50         60 
MNMTKTAMLI ALMTVMFMSI GYLLGGGGGM MIALVIAVAM NLFGYWNSDK MVLRMYNAQE 

        70         80         90        100        110        120 
VDERSAPEYY RMVSGLAANA GLPMPKVYII HEDQPNAFAT GRNPENAAVA ATTGLLNWLS 

       130        140        150        160        170        180 
PEEVAGVMAH ELAHVQNRDT LTMTIVATLA GAISMLGNFA FFLGGNRENG NGVMGVVGTL 

       190        200        210        220        230        240 
LAMIVAPFGA MIVQMAVSRT REYAADKRGA EICGNPLWLS SALGKIARGA KVIPNEEAEH 

       250        260        270        280        290        300 
NPATAHMFII NPLSGRGADN LFSTHPDTDN RIAALEQMAA ETGIRSAAMT ARAAAPSQNS 

       310        320 
GPWGQRSDNA GGNSNGGSRY RGPWS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL51418.1. Different initiation.
PIRAG3281.
RefSeqNP_539154.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YJ50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0236.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL51418; AAL51418; BMEI0236.
GeneID1195948.
KEGGbme:BMEI0236.
PATRIC17850470. VBIBruMel92729_0258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000227301.
KOK03799.
OMAPETAQMM.
OrthoDBEOG6F55J5.
ProtClustDBPRK01345.

Enzyme and pathway databases

BioCycBMEL224914:GCJ0-247-MONOMER.

Family and domain databases

HAMAPMF_00188. Pept_M48_protease_HtpX.
InterProIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamPF01435. Peptidase_M48. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTPX_BRUME
AccessionPrimary (citable) accession number: Q8YJ50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names