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Q8YJ50

- HTPX_BRUME

UniProt

Q8YJ50 - HTPX_BRUME

Protein

Protease HtpX homolog

Gene

htpX

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (19 Oct 2002)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi130 – 1301Zinc; catalyticUniRule annotation
    Active sitei131 – 1311UniRule annotation
    Metal bindingi134 – 1341Zinc; catalyticUniRule annotation
    Metal bindingi202 – 2021Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-247-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protease HtpX homologUniRule annotation (EC:3.4.24.-UniRule annotation)
    Gene namesi
    Name:htpXUniRule annotation
    Ordered Locus Names:BMEI0236
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Protease HtpX homologPRO_0000138854Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI0236.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YJ50.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalUniRule annotationAdd
    BLAST
    Transmembranei145 – 16521HelicalUniRule annotationAdd
    BLAST
    Transmembranei173 – 19321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M48B family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000227301.
    KOiK03799.
    OMAiETSAPQF.
    OrthoDBiEOG6F55J5.

    Family and domain databases

    HAMAPiMF_00188. Pept_M48_protease_HtpX.
    InterProiIPR022919. Pept_M48_protease_HtpX.
    IPR001915. Peptidase_M48.
    [Graphical view]
    PfamiPF01435. Peptidase_M48. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YJ50-1 [UniParc]FASTAAdd to Basket

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    MNMTKTAMLI ALMTVMFMSI GYLLGGGGGM MIALVIAVAM NLFGYWNSDK    50
    MVLRMYNAQE VDERSAPEYY RMVSGLAANA GLPMPKVYII HEDQPNAFAT 100
    GRNPENAAVA ATTGLLNWLS PEEVAGVMAH ELAHVQNRDT LTMTIVATLA 150
    GAISMLGNFA FFLGGNRENG NGVMGVVGTL LAMIVAPFGA MIVQMAVSRT 200
    REYAADKRGA EICGNPLWLS SALGKIARGA KVIPNEEAEH NPATAHMFII 250
    NPLSGRGADN LFSTHPDTDN RIAALEQMAA ETGIRSAAMT ARAAAPSQNS 300
    GPWGQRSDNA GGNSNGGSRY RGPWS 325
    Length:325
    Mass (Da):34,472
    Last modified:October 19, 2002 - v2
    Checksum:i92F2DBFD8D8B4D13
    GO

    Sequence cautioni

    The sequence AAL51418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51418.1. Different initiation.
    PIRiAG3281.
    RefSeqiNP_539154.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51418; AAL51418; BMEI0236.
    GeneIDi1195948.
    KEGGibme:BMEI0236.
    PATRICi17850470. VBIBruMel92729_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51418.1 . Different initiation.
    PIRi AG3281.
    RefSeqi NP_539154.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YJ50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51418 ; AAL51418 ; BMEI0236 .
    GeneIDi 1195948.
    KEGGi bme:BMEI0236.
    PATRICi 17850470. VBIBruMel92729_0258.

    Phylogenomic databases

    HOGENOMi HOG000227301.
    KOi K03799.
    OMAi ETSAPQF.
    OrthoDBi EOG6F55J5.

    Enzyme and pathway databases

    BioCyci BMEL224914:GCJ0-247-MONOMER.

    Family and domain databases

    HAMAPi MF_00188. Pept_M48_protease_HtpX.
    InterProi IPR022919. Pept_M48_protease_HtpX.
    IPR001915. Peptidase_M48.
    [Graphical view ]
    Pfami PF01435. Peptidase_M48. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiHTPX_BRUME
    AccessioniPrimary (citable) accession number: Q8YJ50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3