ATP synthase subunit beta - Brucella melitensis

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Reviewed, UniProtKB/Swiss-Prot Q8YJ35 (ATPB_BRUME)

Last modified December 15, 2009. Version 63. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    ATP synthase subunit beta
    EC=3.6.3.14
Alternative name(s):
    F-ATPase subunit beta
    ATP synthase F1 sector subunit beta

Gene names

Name:	atpD
Ordered Locus Names:	BMEI0251

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

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Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits By similarity.
Catalytic activity	ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out). HAMAP MF_01347
Subunit structure	F-type ATPases have 2 components, CF₁ - the catalytic core - and CF₀ - the membrane proton channel. CF₁ has five subunits: alpha₃, beta₃, gamma₁, delta₁, epsilon₁. CF₀ has three main subunits: a₁, b₂ and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF₁ is attached to CF₀ by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

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Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP hydrogen-exporting ATPase activity, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 521

521

ATP synthase subunit beta HAMAP MF_01347

PRO_0000254228

Regions

Nucleotide binding

199 – 206

ATP By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8YJ35-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: AB6F0218215EF704
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FASTA

521

54,791

        10         20         30         40         50         60 
MAKAATPKTT AAAEAKPAAK APAKKAAPKT TAAAKPAATK SGAPKAAAAG AIGHITQVIG 

        70         80         90        100        110        120 
AVVDVKFPEG QLPLILNALE VDNQGHRLVL EVAQHLGEDT VRTIAMDATE GLVRGQEARD 

       130        140        150        160        170        180 
TGEPIMVPVG VETLGRIMNV IGEPVDEAGP IKTKATRAIH QNAPEYIEQS TEAEILVTGI 

       190        200        210        220        230        240 
KVVDLLAPYA KGGKIGLFGG AGVGKTVLIM ELINNVAKAH GGYSVFAGVG ERTREGNDLY 

       250        260        270        280        290        300 
HEMIESGVNK LGGGEGSKAA LVYGQMNEPP GARARVALSG LTVAENFRDQ GQDVLFFVDN 

       310        320        330        340        350        360 
IFRFTQAGSE VSALLGRIPS AVGYQPTLAT DMGAMQERIT TTTKGSITSV QAIYVPADDL 

       370        380        390        400        410        420 
TDPAPATSFA HLDATTVLSR SIAEKGIYPA VDPLDSTSRM LDPKVVGEEH YAVARQVQSI 

       430        440        450        460        470        480 
LQRYKALQDI IAILGMDELS EEDKLTVARA RKIERFLSQP FFVAEVFTGS PGKLVDLADT 

       490        500        510        520 
IKGFKGLCAG DYDHLPEAAF YMVGSIEEAL EKAKKLAAEA A

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References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis."
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E.

Overbeek R.
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

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Cross-references

Sequence databases
	AE008917 Genomic DNA. Translation: AAL51433.1.
PIR	AF3283.
RefSeq	NP_539169.1.
3D structure databases
HSSP	HSSP built from PDB template 1H8E based on UniProtKB P00829.
SMR	Q8YJ35. Positions 53-517.
ModBase	Search...
Genome annotation databases
GeneID	1195963.
GenomeReviews	Gene locus BMEI0251 in contig AE008917_GR.
KEGG	bme:BMEI0251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG565875.
OMA	IGQEHYD.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0251-MON.
BRENDA	3.6.3.14. 277959.
Family and domain databases
HAMAP	MF_01347. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR005722. ATPase_F1-cplx_bsu. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
PANTHER	PTHR15184:SF8. ATPase_F1_b. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ATPB_BRUME

Accession

Primary (citable) accession number: Q8YJ35

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 1, 2002
Last modified:	December 15, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents