Q8YJ15 (MTGA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monofunctional biosynthetic peptidoglycan transglycosylase
Short name=Monofunctional TGase
EC=2.4.2.-

Gene names

Name:	mtgA
Ordered Locus Names:	BMEI0271

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP-Rule MF_00766
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00766
Subcellular location	Cell membrane; Single-pass membrane protein Potential HAMAP-Rule MF_00766.
Sequence similarities	Belongs to the glycosyltransferase 51 family.
Sequence caution	The sequence AAL51453.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Monofunctional biosynthetic peptidoglycan transglycosylase HAMAP-Rule MF_00766		PRO_0000083121
Regions
	Transmembrane	12 – 32	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YJ15 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: 2837EFDE814E8D89	FASTA	224	24,712
	10 20 30 40 50 60 MWGSRIAVAL RILVVLAILP VFLLLVYSLP FVRPVSTLMV KDYALLQGVN RQWVDIENIA 70 80 90 100 110 120 PVLVNSVMMA EDGQFCSHGG VDWHQLGLVL DDAGDGGPSR GASTITMQMV KNLFLWNGRS 130 140 150 160 170 180 YLRKGLEFPL ALIADAVLSR KRIMEIYLNI AEWGPGIYGI EAAARHYFKR SAAKLTARQA 190 200 210 220 ALLAVTLPNP ALRNPAKPTR NMQRIARIVA GRAMRSGPYV TCVK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51453.1. Different initiation.
PIR	AB3286.
RefSeq	NP_539189.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YJ15.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0271.
Protein family/group databases
CAZy	GT51. Glycosyltransferase Family 51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51453; AAL51453; BMEI0271.
GeneID	1195983.
KEGG	bme:BMEI0271.
PATRIC	17850548. VBIBruMel92729_0296.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000288116.
KO	K03814.
OMA	SEDGQFC.
ProtClustDB	PRK00056.
Enzyme and pathway databases
BioCyc	BMEL224914:GCJ0-282-MONOMER.
UniPathway	UPA00219.
Family and domain databases
HAMAP	MF_00766. Mono_pep_trsgly.
InterPro	IPR001264. Glyco_trans_51. IPR011812. Mono_pep_trsgly. [Graphical view]
Pfam	PF00912. Transgly. 1 hit. [Graphical view]
TIGRFAMs	TIGR02070. mono_pep_trsgly. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTGA_BRUME

Accession

Primary (citable) accession number: Q8YJ15

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	May 29, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program