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Q8YJ03 (THIP_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine transport system permease protein ThiP
Gene names
Name:thiP
Ordered Locus Names:BMEI0284
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane By similarity.

Subunit structure

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB) Probable.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.

Contains 2 ABC transmembrane type-1 domains.

Sequence caution

The sequence AAL51465.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthiamine transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Thiamine transport system permease protein ThiP
PRO_0000282909

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane64 – 8421Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane406 – 42621Helical; Potential
Transmembrane468 – 48821Helical; Potential
Transmembrane510 – 53021Helical; Potential
Domain62 – 266205ABC transmembrane type-1 1
Domain339 – 530192ABC transmembrane type-1 2

Sequences

Sequence LengthMass (Da)Tools
Q8YJ03 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 5FADDDB7893B96AA

FASTA54358,303
        10         20         30         40         50         60 
MTATPARRTS LASPATKPVA GGLALAFLAT LAGGALLALA LEAGGGGFDA AANFDTYLWR 

        70         80         90        100        110        120 
VARFTIWQAV ASSLLSVLFA IPIARALYAE ARFPGRGLIL RLFAQPLALP ALVAVLGVTS 

       130        140        150        160        170        180 
IYGRNGLIAH ISDMLGHPMQ PDIYGIAGIL IAHIFFNMPL AVRLLLAAYE SIPDDHWKLA 

       190        200        210        220        230        240 
AQLGMGSRAR FRLIDWPVIR RSLPGMIGLV FMLCVTSFTT VLTLGGGPRA TTLEVAIYQS 

       250        260        270        280        290        300 
LHFDFDPARA VALTFTQLAL TLLILLILRL TGRPSEEGFT QTATPRRYGS PRKTERLFNI 

       310        320        330        340        350        360 
IVIALGFLYV ALPIAGVVVS GLTADLVRLL SERIVWHAIA TSLALGFSAA LLAVFLSLAL 

       370        380        390        400        410        420 
VAAREATRNA RIANIFDTGA SLILVMPPIV IGAGWFILLR HFTDPFVMAP LMVVTVNAAM 

       430        440        450        460        470        480 
AMPFAVRLLR PAWDTAASRH NKLCSQLGIK GFNRLRLIDW PSIRRPCGMA FAFAMALSLG 

       490        500        510        520        530        540 
DLGTIALFGS DALVTLPYLL LQRMGSYRTF DAAGLALILG VLCLALMMIA DRAAASRKEA 


FLQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL51465.1. Different initiation.
PIRAF3287.
RefSeqNP_539201.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YJ03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0284.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL51465; AAL51465; BMEI0284.
GeneID1195995.
KEGGbme:BMEI0284.
PATRIC17850580. VBIBruMel92729_0312.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000272487.
KOK02063.
OMAPLYLFQL.
OrthoDBEOG6JDW8K.
ProtClustDBPRK09433.

Enzyme and pathway databases

BioCycBMEL224914:GCJ0-294-MONOMER.

Family and domain databases

Gene3D1.10.3720.10. 2 hits.
InterProIPR000515. MetI-like.
IPR005947. ThiP_ABC_transpt.
[Graphical view]
PfamPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMSSF161098. SSF161098. 2 hits.
TIGRFAMsTIGR01253. thiP. 1 hit.
PROSITEPS50928. ABC_TM1. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIP_BRUME
AccessionPrimary (citable) accession number: Q8YJ03
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names