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Q8YJ03

- THIP_BRUME

UniProt

Q8YJ03 - THIP_BRUME

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Protein

Thiamine transport system permease protein ThiP

Gene

thiP

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane (By similarity).By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. thiamine transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transport system permease protein ThiP
Gene namesi
Name:thiP
Ordered Locus Names:BMEI0284
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cell inner membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Thiamine transport system permease protein ThiPPRO_0000282909Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).Curated

Protein-protein interaction databases

STRINGi224914.BMEI0284.

Structurei

3D structure databases

ProteinModelPortaliQ8YJ03.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei64 – 8421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei142 – 16221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei300 – 32021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei343 – 36321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei379 – 39921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei406 – 42621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei468 – 48821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei510 – 53021HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 266205ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 530192ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000272487.
KOiK02063.
OMAiSYRTNDA.
OrthoDBiEOG6JDW8K.

Family and domain databases

Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
IPR005947. ThiP_ABC_transpt.
[Graphical view]
PfamiPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
TIGRFAMsiTIGR01253. thiP. 1 hit.
PROSITEiPS50928. ABC_TM1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YJ03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATPARRTS LASPATKPVA GGLALAFLAT LAGGALLALA LEAGGGGFDA
60 70 80 90 100
AANFDTYLWR VARFTIWQAV ASSLLSVLFA IPIARALYAE ARFPGRGLIL
110 120 130 140 150
RLFAQPLALP ALVAVLGVTS IYGRNGLIAH ISDMLGHPMQ PDIYGIAGIL
160 170 180 190 200
IAHIFFNMPL AVRLLLAAYE SIPDDHWKLA AQLGMGSRAR FRLIDWPVIR
210 220 230 240 250
RSLPGMIGLV FMLCVTSFTT VLTLGGGPRA TTLEVAIYQS LHFDFDPARA
260 270 280 290 300
VALTFTQLAL TLLILLILRL TGRPSEEGFT QTATPRRYGS PRKTERLFNI
310 320 330 340 350
IVIALGFLYV ALPIAGVVVS GLTADLVRLL SERIVWHAIA TSLALGFSAA
360 370 380 390 400
LLAVFLSLAL VAAREATRNA RIANIFDTGA SLILVMPPIV IGAGWFILLR
410 420 430 440 450
HFTDPFVMAP LMVVTVNAAM AMPFAVRLLR PAWDTAASRH NKLCSQLGIK
460 470 480 490 500
GFNRLRLIDW PSIRRPCGMA FAFAMALSLG DLGTIALFGS DALVTLPYLL
510 520 530 540
LQRMGSYRTF DAAGLALILG VLCLALMMIA DRAAASRKEA FLQ
Length:543
Mass (Da):58,303
Last modified:April 3, 2007 - v2
Checksum:i5FADDDB7893B96AA
GO

Sequence cautioni

The sequence AAL51465.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51465.1. Different initiation.
PIRiAF3287.
RefSeqiNP_539201.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51465; AAL51465; BMEI0284.
GeneIDi1195995.
KEGGibme:BMEI0284.
PATRICi17850580. VBIBruMel92729_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL51465.1 . Different initiation.
PIRi AF3287.
RefSeqi NP_539201.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YJ03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL51465 ; AAL51465 ; BMEI0284 .
GeneIDi 1195995.
KEGGi bme:BMEI0284.
PATRICi 17850580. VBIBruMel92729_0312.

Phylogenomic databases

HOGENOMi HOG000272487.
KOi K02063.
OMAi SYRTNDA.
OrthoDBi EOG6JDW8K.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-294-MONOMER.

Family and domain databases

Gene3Di 1.10.3720.10. 2 hits.
InterProi IPR000515. MetI-like.
IPR005947. ThiP_ABC_transpt.
[Graphical view ]
Pfami PF00528. BPD_transp_1. 2 hits.
[Graphical view ]
SUPFAMi SSF161098. SSF161098. 2 hits.
TIGRFAMsi TIGR01253. thiP. 1 hit.
PROSITEi PS50928. ABC_TM1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiTHIP_BRUME
AccessioniPrimary (citable) accession number: Q8YJ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3