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Protein

Thiamine transport system permease protein ThiP

Gene

thiP

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane (By similarity).By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. thiamine transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transport system permease protein ThiP
Gene namesi
Name:thiP
Ordered Locus Names:BMEI0284
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cell inner membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei64 – 8421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei142 – 16221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei300 – 32021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei343 – 36321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei379 – 39921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei406 – 42621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei468 – 48821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei510 – 53021HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Thiamine transport system permease protein ThiPPRO_0000282909Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).Curated

Protein-protein interaction databases

STRINGi224914.BMEI0284.

Structurei

3D structure databases

ProteinModelPortaliQ8YJ03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 266205ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 530192ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000272487.
KOiK02063.
OMAiPLYLFQL.
OrthoDBiEOG6JDW8K.

Family and domain databases

Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
IPR005947. ThiP_ABC_transpt.
[Graphical view]
PfamiPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
TIGRFAMsiTIGR01253. thiP. 1 hit.
PROSITEiPS50928. ABC_TM1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YJ03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATPARRTS LASPATKPVA GGLALAFLAT LAGGALLALA LEAGGGGFDA
60 70 80 90 100
AANFDTYLWR VARFTIWQAV ASSLLSVLFA IPIARALYAE ARFPGRGLIL
110 120 130 140 150
RLFAQPLALP ALVAVLGVTS IYGRNGLIAH ISDMLGHPMQ PDIYGIAGIL
160 170 180 190 200
IAHIFFNMPL AVRLLLAAYE SIPDDHWKLA AQLGMGSRAR FRLIDWPVIR
210 220 230 240 250
RSLPGMIGLV FMLCVTSFTT VLTLGGGPRA TTLEVAIYQS LHFDFDPARA
260 270 280 290 300
VALTFTQLAL TLLILLILRL TGRPSEEGFT QTATPRRYGS PRKTERLFNI
310 320 330 340 350
IVIALGFLYV ALPIAGVVVS GLTADLVRLL SERIVWHAIA TSLALGFSAA
360 370 380 390 400
LLAVFLSLAL VAAREATRNA RIANIFDTGA SLILVMPPIV IGAGWFILLR
410 420 430 440 450
HFTDPFVMAP LMVVTVNAAM AMPFAVRLLR PAWDTAASRH NKLCSQLGIK
460 470 480 490 500
GFNRLRLIDW PSIRRPCGMA FAFAMALSLG DLGTIALFGS DALVTLPYLL
510 520 530 540
LQRMGSYRTF DAAGLALILG VLCLALMMIA DRAAASRKEA FLQ
Length:543
Mass (Da):58,303
Last modified:April 3, 2007 - v2
Checksum:i5FADDDB7893B96AA
GO

Sequence cautioni

The sequence AAL51465.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51465.1. Different initiation.
PIRiAF3287.
RefSeqiNP_539201.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL51465; AAL51465; BMEI0284.
GeneIDi1195995.
KEGGibme:BMEI0284.
PATRICi17850580. VBIBruMel92729_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51465.1. Different initiation.
PIRiAF3287.
RefSeqiNP_539201.1. NC_003317.1.

3D structure databases

ProteinModelPortaliQ8YJ03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI0284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL51465; AAL51465; BMEI0284.
GeneIDi1195995.
KEGGibme:BMEI0284.
PATRICi17850580. VBIBruMel92729_0312.

Phylogenomic databases

HOGENOMiHOG000272487.
KOiK02063.
OMAiPLYLFQL.
OrthoDBiEOG6JDW8K.

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-294-MONOMER.

Family and domain databases

Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
IPR005947. ThiP_ABC_transpt.
[Graphical view]
PfamiPF00528. BPD_transp_1. 2 hits.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
TIGRFAMsiTIGR01253. thiP. 1 hit.
PROSITEiPS50928. ABC_TM1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiTHIP_BRUME
AccessioniPrimary (citable) accession number: Q8YJ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.