Reviewed, UniProtKB/Swiss-Prot Q8YIW2 (EFP_BRUME)

Names and origin

Protein names

Recommended name:
    Elongation factor P
      Short name=EF-P

Gene names

Name:	efp
Ordered Locus Names:	BMEI0327

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase By similarity.
Pathway	Protein biosynthesis; polypeptide chain elongation. HAMAP MF_00141
Subcellular location	Cytoplasm HAMAP MF_00141.
Sequence similarities	Belongs to the elongation factor P family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Elongation factor P HAMAP MF_00141		PRO_0000094213

Sequences

	Sequence		Length	Mass (Da)
	Q8YIW2-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 0DB78F78885EC53A	FASTA	186	20,700
	10 20 30 40 50 60 MKINGNEIRP GNVIEHEGGL WVAVKTNAVK PGKGGAYNQV ELKNLINGTK LNERFRAAES 70 80 90 100 110 120 VERVRLEQKD FSFLYEQGEA LIFMDTETYE QLELQKDFVG DRAAFLQDGM MVTVELYEEK 130 140 150 160 170 180 PIGIRLPDQV TLAITEADPV VKGQTAASSY KPAVLENGIR IPVPPFIASG ERVIVDTNEL TYISRA

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008917 Genomic DNA. Translation: AAL51508.1.
PIR	AI3292.
RefSeq	NP_539244.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1196038.
GenomeReviews	Gene locus BMEI0327 in contig AE008917_GR.
KEGG	bme:BMEI0327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG303311.
OMA	MISSNDF.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0327-MON.
Family and domain databases
HAMAP	MF_00141. [Tree]
InterPro	IPR015365. Elong-fact-P_C. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR020599. Transl_elong_fac_P/YeiP. IPR013185. Transl_elong_KOW-like. IPR001059. Transl_elong_P/YeiP_cen. IPR013852. Transl_elong_P/YeiP_CS. IPR011768. Transl_elongation_fac_P. IPR014722. Transl_SH3-like_sub. IPR008991. Translation_prot_SH3-like. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 2 hits. G3DSA:2.30.30.30. Ribosomal_L2. 1 hit.
Pfam	PF01132. EFP. 1 hit. PF08207. EFP_N. 1 hit. PF09285. Elong-fact-P_C. 1 hit. [Graphical view]
PIRSF	PIRSF005901. EF-P. 1 hit.
SMART	SM00841. Elong-fact-P_C. 1 hit. [Graphical view]
PROSITE	PS01275. EFP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFP_BRUME

Accession

Primary (citable) accession number: Q8YIW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	March 1, 2002
Last modified:	December 15, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)