Holliday junction ATP-dependent DNA helicase ruvB - Brucella melitensis

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Reviewed, UniProtKB/Swiss-Prot Q8YIV5 (RUVB_BRUME)

Last modified December 15, 2009. Version 55. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Holliday junction ATP-dependent DNA helicase ruvB
EC=3.6.1.-

Gene names

Name:	ruvB
Ordered Locus Names:	BMEI0334

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing By similarity.
Subunit structure	Forms a complex with ruvA By similarity.
Sequence similarities	Belongs to the ruvB family.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair SOS response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repair Inferred from electronic annotation. Source: HAMAP SOS response Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: InterPro four-way junction helicase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

346

Holliday junction ATP-dependent DNA helicase ruvB HAMAP MF_00016

PRO_0000165505

Regions

Nucleotide binding

8

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8YIV5-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F97710688F919FBC
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346

38,269

        10         20         30         40         50         60 
MSDRNPLIDA DRRADEDNTL RPQTLDDFVG QAAARANLKV FIEAAKVRGE ALDHVLFVGP 

        70         80         90        100        110        120 
PGLGKTTLAQ IMAKELGVNF RSTSGPVIAK AGDLAALLTN LEERDVLFID EIHRLSPAVE 

       130        140        150        160        170        180 
EILYPAMEDF QLDLIIGEGP AARSVKIDLA KFTLVAATTR LGLLTTPLRD RFGIPVRLNF 

       190        200        210        220        230        240 
YTVEELEYIV RRGARIMQMG ISSDGAREVA RRSRGTPRIV GRLLRRVRDF ALVAGADIID 

       250        260        270        280        290        300 
RRIADEALSR LEVDNRGLDQ LDRRYLNIIA RNFGGGPVGI ETIAAGLSEP RDAIEDIIEP 

       310        320        330        340 
YLIQQGFLQR TPRGRVLTAV AWQHLGLPAP AEIIQQSQYG LFMEDE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis."
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E.

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Overbeek R.
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
	AE008917 Genomic DNA. Translation: AAL51515.1.
PIR	AH3293.
RefSeq	NP_539251.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1196045.
GenomeReviews	Gene locus BMEI0334 in contig AE008917_GR.
KEGG	bme:BMEI0334.
NMPDR	fig\|224914.1.peg.333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG339960.
OMA	EKFDGGP.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0334-MON.
Family and domain databases
HAMAP	MF_00016. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR000641. CbxX_CfqX. IPR004605. DNA_helicase_Holl-junc_RuvB. IPR008823. DNA_helicase_Holl-junc_RuvB_C. IPR008824. DNA_helicase_Holl-junc_RuvB_N. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00004. AAA. 1 hit. PF05491. RuvB_C. 1 hit. PF05496. RuvB_N. 1 hit. [Graphical view]
PRINTS	PR00819. CBXCFQXSUPER.
ProDom	PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RUVB_BRUME

Accession

Primary (citable) accession number: Q8YIV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	March 1, 2002
Last modified:	December 15, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents