Q8YIG3 (RL25_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L25

Alternative name(s):
General stress protein CTC

Gene names

Name:	rplY
Synonyms:	ctc
Ordered Locus Names:	BMEI0481

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance By similarity. HAMAP-Rule MF_01334
Subunit structure	Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18 By similarity.
Sequence similarities	Belongs to the ribosomal protein L25P family. Ctc subfamily.
Sequence caution	The sequence AAL51662.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	5S rRNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	50S ribosomal protein L25 HAMAP-Rule MF_01334		PRO_0000181525

Sequences

	Sequence		Length	Mass (Da)
	Q8YIG3 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 24DD3507AD4C5492	FASTA	207	22,383
	10 20 30 40 50 60 MSETYVLKAD LRTRVGKGSS RELRRNGQIP AVIYGDKQEP LAIAVSYKEI FYKIHGGGFK 70 80 90 100 110 120 TTVATIEVDG KKIQVLPKDY QLDPVRDFPQ HVDFLRVSAK SVVHVNVPVH FKNEEAAPGI 130 140 150 160 170 180 KRGGVLNVVR HDVELIVPAN AIPEALEIDL SGLEIGDSVH ISAVKLPKGA TPAIQDRDFT 190 200 IATIAAPAGL KSEENAEGAA EEAKDGE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51662.1. Different initiation.
PIR	AC3312.
RefSeq	NP_539398.2. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YIG3.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0481.
Proteomic databases
PRIDE	Q8YIG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51662; AAL51662; BMEI0481.
GeneID	1196192.
KEGG	bme:BMEI0481.
PATRIC	17851060. VBIBruMel92729_0540.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000214907.
KO	K02897.
OMA	ANVHAPR.
ProtClustDB	PRK05618.
Family and domain databases
Gene3D	2.170.120.20. 1 hit. 2.40.240.10. 1 hit.
HAMAP	MF_01334. Ribosomal_L25_CTC.
InterPro	IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR020057. Ribosomal_L25_b-dom. IPR001021. Ribosomal_L25_long. IPR020055. Ribosomal_L25_short. [Graphical view]
Pfam	PF01386. Ribosomal_L25p. 1 hit. [Graphical view]
ProDom	PD012503. Ribosomal_L25. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50715. Ribosomal_L25rel. 1 hit.
TIGRFAMs	TIGR00731. ctc_TL5. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RL25_BRUME

Accession

Primary (citable) accession number: Q8YIG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program