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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.By similarity

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferase (EC:2.1.1.144)
Gene namesi
Name:tam
Ordered Locus Names:BMEI0554
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Trans-aconitate 2-methyltransferasePRO_0000218077Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2533.

Structurei

3D structure databases

ProteinModelPortaliQ8YI91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OrthoDBiEOG6716PV.

Family and domain databases

Gene3Di1.10.150.290. 2 hits.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YI91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDWSAKQYL KFEDEXSRPA RDLLAQIPLS APRKVVDIGC GPGNSTKLLV
60 70 80 90 100
ERWPDAQISG FDTSPDMIDT AKTHLPDVEF FISDAASFEP DAETDVLFSN
110 120 130 140 150
AVFQWLPDHV EQLQRLLSLL QPGAFLAVQM PDNMGEQTHV GMRDVAKTAP
160 170 180 190 200
FAMEIATKGR AALPPVATYY NAFADDAARI DIWHTIYNHP LAGVDAIVEW
210 220 230 240 250
VKGTGLRPFL DPLDEQEQAD YLKAYKARIA EHYPMTADGK VLLRFPRIFL

VVQKK
Length:255
Mass (Da):28,568
Last modified:June 6, 2002 - v2
Checksum:iB1AA641CEEBADAC5
GO

Sequence cautioni

The sequence AAL51735.1 differs from that shown. Reason: Frameshift at position 16. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51735.1. Frameshift.
PIRiAD3321.

Genome annotation databases

EnsemblBacteriaiAAL51735; AAL51735; BMEI0554.
KEGGibme:BMEI0554.
PATRICi17851229. VBIBruMel92729_0623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51735.1. Frameshift.
PIRiAD3321.

3D structure databases

ProteinModelPortaliQ8YI91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_2533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL51735; AAL51735; BMEI0554.
KEGGibme:BMEI0554.
PATRICi17851229. VBIBruMel92729_0623.

Phylogenomic databases

eggNOGiENOG4107R6G. Bacteria.
COG4106. LUCA.
HOGENOMiHOG000125295.
KOiK00598.
OrthoDBiEOG6716PV.

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-576-MONOMER.

Family and domain databases

Gene3Di1.10.150.290. 2 hits.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiTAM_BRUME
AccessioniPrimary (citable) accession number: Q8YI91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: May 11, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.