Reviewed, UniProtKB/Swiss-Prot Q8YI59 (LPXC_BRUME)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
    EC=3.5.1.-
Alternative name(s):
    UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	BMEI0586

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid (IV)A biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the lpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388		PRO_0000191919

Sequences

	Sequence		Length	Mass (Da)
	Q8YI59-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 90180ACC07F361DE	FASTA	286	30,867
	10 20 30 40 50 60 MNAYQKTIGR AVTLSGVGIH GGAPASARLL PADADTGILF QRSDIKDSAP VCAHVSQIGA 70 80 90 100 110 120 TDLCTSLGAR EARIDTVEHL MAAISALGID NLVVEIEGPE VPILDGTSAR FIEAVDSVGV 130 140 150 160 170 180 VTQDAKRRFI RILKTVRVEA GNSWGEFRPY DGTRFEVEID FECPLIGRQK FAHDVDEETF 190 200 210 220 230 240 RKELSTARTF GFMKDVERLW AAGLALGASL DNSLVIGDDN SIVNADGLRF KDEFVRHKTL 250 260 270 280 DAVGDLALAG LPFIGCFSSY RGGHRLNSEA VKALLSDETA FEIIEA

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009500 Genomic DNA. Translation: AAL51767.1.
PIR	AD3325.
RefSeq	NP_539503.1.
3D structure databases
HSSP	HSSP built from PDB template 1P42 based on UniProtKB O67648.
ModBase	Search...
Genome annotation databases
GeneID	1196297.
GenomeReviews	Gene locus BMEI0586 in contig AE008917_GR.
KEGG	bme:BMEI0586.
NMPDR	fig|224914.1.peg.585.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YI59.
OMA	Q8YI59. TGVGVHS.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI0586-MON.
Family and domain databases
HAMAP	MF_00388. [Tree]
InterPro	IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
ProDom	PD011499. Lipid_A_LpxC. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00325. lpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_BRUME

Accession

Primary (citable) accession number: Q8YI59

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)