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Q8YI21

- ILVC_BRUME

UniProt

Q8YI21 - ILVC_BRUME

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:BMEI0624
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Ketol-acid reductoisomerasePRO_0000151284Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI0624.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YI21.
    SMRiQ8YI21. Positions 1-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiQSDVIMA.
    OrthoDBiEOG625K07.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YI21-1 [UniParc]FASTAAdd to Basket

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    MRVYYDRDAD VNLIKSKKVV IVGYGSQGRA HALNLKDSGA ANVRVALREG    50
    SATVQKAQAD GFEVMNVADA AKWADLMMMA TPDELQADIY RDHIHNNLRD 100
    GAAIAFAHGL NVHCGLIEPK KTVDVMMIAP KGPGHTVRGE YQKGGGVPCL 150
    IAIHQDASGN AHDLALSYAS GVGGGRSGVI ETTFKEECET DLFGEQAVLC 200
    GGVVELIRTG FEVLVEAGYA PEMAYFECLN EMKLIVDLIY EGGIANMNYS 250
    ISNTAEWGEY VTGPRIITAE TKAEMKRVLK DIQTGKFTSD WMQEWKAGAA 300
    RFKGIRRLND AHQIEEVGGK LRAMMPWIEK NKLVDKARN 339
    Length:339
    Mass (Da):37,080
    Last modified:March 1, 2002 - v1
    Checksum:i1A4967D9205EEE92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51805.1.
    PIRiAB3330.
    RefSeqiNP_539541.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL51805; AAL51805; BMEI0624.
    GeneIDi1196335.
    KEGGibme:BMEI0624.
    PATRICi17801362. VBIBruMel146950_3006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL51805.1 .
    PIRi AB3330.
    RefSeqi NP_539541.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YI21.
    SMRi Q8YI21. Positions 1-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL51805 ; AAL51805 ; BMEI0624 .
    GeneIDi 1196335.
    KEGGi bme:BMEI0624.
    PATRICi 17801362. VBIBruMel146950_3006.

    Phylogenomic databases

    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi QSDVIMA.
    OrthoDBi EOG625K07.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .

    Miscellaneous databases

    PROi Q8YI21.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiILVC_BRUME
    AccessioniPrimary (citable) accession number: Q8YI21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3