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Protein

Putative fluoride ion transporter CrcB 2

Gene

crcB2

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fluoride ion transporter CrcB 2
Gene namesi
Name:crcB2
Ordered Locus Names:BMEI0634
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalAdd BLAST21
Transmembranei35 – 55HelicalAdd BLAST21
Transmembranei67 – 87HelicalAdd BLAST21
Transmembranei96 – 116HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001100721 – 270Putative fluoride ion transporter CrcB 2Add BLAST270

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2610.

Structurei

3D structure databases

ProteinModelPortaliQ8YI11.
SMRiQ8YI11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CrcB (TC 9.B.71) family. [View classification]

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105X2M. Bacteria.
COG0239. LUCA.
COG3439. LUCA.
HOGENOMiHOG000289132.
OMAiIIGMGMM.

Family and domain databases

Gene3Di3.30.310.70. 1 hit.
HAMAPiMF_00454. CrcB. 1 hit.
InterProiView protein in InterPro
IPR003691. CrcB.
IPR005180. DUF302.
IPR035923. TT1751-like_sf.
PANTHERiPTHR28259. PTHR28259. 1 hit.
PfamiView protein in Pfam
PF02537. CRCB. 1 hit.
PF03625. DUF302. 1 hit.
SUPFAMiSSF103247. SSF103247. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YI11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDIIILVVI GGAFGAMTRE FIMLMVPPLT DGFPLDILVA NVVACFLLGT
60 70 80 90 100
VTALYARKIH SRDVHTIIGT GMMGGVSTFS SFAYGSVVLA SASVSAFLIA
110 120 130 140 150
AAYVTVSVVA GYVAVLAGMK FGEKSADILH RYPPMASIID SGLVTVESRH
160 170 180 190 200
SVAETIERVA AKAKSMGMNV FTRVDHGAGA KEAGLGLPPT ELIIFGNPQN
210 220 230 240 250
GTVLMQDKRT IGLDLPIRAL AWEDGSGKVW LTVNDPAWLA QRHSLGLSSD
260 270
VAIKAMVTGT GTVTKYAAGD
Length:270
Mass (Da):28,298
Last modified:March 1, 2002 - v1
Checksum:iA5E8739B22B5E1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51815.1.
PIRiAD3331.
RefSeqiWP_004683989.1. NZ_GG703780.1.

Genome annotation databases

EnsemblBacteriaiAAL51815; AAL51815; BMEI0634.
GeneIDi29593419.
KEGGibme:BMEI0634.
bmel:DK63_792.
PATRICifig|224914.52.peg.829.

Similar proteinsi

Entry informationi

Entry nameiCRCB2_BRUME
AccessioniPrimary (citable) accession number: Q8YI11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families