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Protein

Urease accessory protein UreD 2

Gene

ureD2

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processNickel insertion

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 2UniRule annotation
Gene namesi
Name:ureD2UniRule annotation
Ordered Locus Names:BMEI0643
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003404241 – 302Urease accessory protein UreD 2Add BLAST302

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_2618.

Structurei

3D structure databases

SMRiQ8YI02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108XNJ. Bacteria.
COG0829. LUCA.
HOGENOMiHOG000060675.
KOiK03190.
OMAiVGENAFL.

Family and domain databases

HAMAPiMF_01384. UreD. 1 hit.
InterProiView protein in InterPro
IPR002669. UreD.
PANTHERiPTHR33643. PTHR33643. 1 hit.
PfamiView protein in Pfam
PF01774. UreD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YI02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKARELAN YQDEPEQLPT GSFGKNAFLR LGFERRPERT VLATLHRRAP
60 70 80 90 100
LIVQQALYWD EGMPTLPCVS IISNAGGILQ GDRYAIEIDL EPDTQAHVTT
110 120 130 140 150
QSATRIQEMD ANFATQTQTI TLGANSYLEY IPHPIIPHKH SRFVQQTEVT
160 170 180 190 200
IHPTATLIYS EVLMAGRKYY GTGELFHYDL FSSKFHAAHT DGTSLFTEKF
210 220 230 240 250
IVEPARGNVS RLGAMGSFHV FGNLILLTPK THADRLFETI DPVFDMDEGI
260 270 280 290 300
AWGASRLPND AGLLFKVLGM ESAPVRAAIR KIWEAARQEV TGASLPENFL

WA
Length:302
Mass (Da):33,685
Last modified:March 1, 2002 - v1
Checksum:iBD228D3B2E437E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51824.1.
PIRiAE3332.
RefSeqiWP_002967786.1. NZ_GG703780.1.

Genome annotation databases

EnsemblBacteriaiAAL51824; AAL51824; BMEI0643.
GeneIDi29593429.
KEGGibme:BMEI0643.
bmel:DK63_784.
PATRICifig|224914.52.peg.821.

Similar proteinsi

Entry informationi

Entry nameiURED2_BRUME
AccessioniPrimary (citable) accession number: Q8YI02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families