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Protein

Cobyric acid synthase

Gene

cobQ

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei333NucleophileUniRule annotation1
Active sitei430UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobyric acid synthaseUniRule annotation
Gene namesi
Name:cobQUniRule annotation
Ordered Locus Names:BMEI0690
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001412901 – 483Cobyric acid synthaseAdd BLAST483

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2663.

Structurei

3D structure databases

ProteinModelPortaliQ8YHV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 438GATase cobBQ-typeUniRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the CobB/CobQ family. CobQ subfamily.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105CAA. Bacteria.
COG1492. LUCA.
HOGENOMiHOG000224803.
KOiK02232.
OMAiQVIIHGR.

Family and domain databases

CDDicd01750. GATase1_CobQ. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00028. CobQ. 1 hit.
InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR033949. CobQ_GATase1.
IPR004459. CobQ_synth.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
PANTHERiPTHR21343:SF1. PTHR21343:SF1. 1 hit.
PfamiView protein in Pfam
PF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00313. cobQ. 1 hit.
PROSITEiView protein in PROSITE
PS51274. GATASE_COBBQ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YHV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAIMFQGT GSDVGKSVLV AGLCRVARNR GLKVRPFKPQ NMSNNAAVSD
60 70 80 90 100
DGGEIGRAQW LQALACGVPS SVHMNPVLLK PQTDMGSQLI VQGQVRGEAR
110 120 130 140 150
GRYYQELKPQ LMAAVMESFA KVGDGADLVL VEGAGSPAEI NLRAGDIANM
160 170 180 190 200
GFATHADVPV VLVGDIDRGG VIASLVGTHT ILPQEDRAMV RGFLINKFRG
210 220 230 240 250
DISLFDDSLA AITRFTGWRS FGVVPWLKAV SRLPAEDSVV LERAVRGDKK
260 270 280 290 300
ALIVAVPMLP RIANFDDLDP LKAEPAVEVV MVPPGSSLPA DAGLVVLPGT
310 320 330 340 350
KSTIADLLAL RENGWDRELV AHVKRGGHVL GICGGFQMLG RRISDPAGIE
360 370 380 390 400
GNVRDIEGLG LLDIETMTEP EKVVRNVEAV SLLHDEPLEG YEIHIGRTSG
410 420 430 440 450
PDMARPFARI GDHDDGAVSP DGRIMGTYLH GVFSADRFRH HFLRALGVEG
460 470 480
GQMNYRESVE EALGELAEGL EASLDIDGLF ALA
Length:483
Mass (Da):51,647
Last modified:October 31, 2003 - v2
Checksum:i1D4DEC4417BF5C67
GO

Sequence cautioni

Q8YHV6: The sequence AAL51871 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL51871.1. Different initiation.
PIRiAD3338.
RefSeqiWP_004683961.1. NZ_GG703780.1.

Genome annotation databases

EnsemblBacteriaiAAL51871; AAL51871; BMEI0690.
GeneIDi29593476.
KEGGibme:BMEI0690.
bmel:DK63_738.
PATRICifig|224914.52.peg.771.

Similar proteinsi

Entry informationi

Entry nameiCOBQ_BRUME
AccessioniPrimary (citable) accession number: Q8YHV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: October 25, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families