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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBMEL224914:G1FZL-749-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:BMEI0703
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001416581 – 369Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST369

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2676

Structurei

3D structure databases

ProteinModelPortaliQ8YHU3
SMRiQ8YHU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YHU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDETTPANK NPEKAELRCG WTTGACATAA TKAALTALIT GEFPDPVGII
60 70 80 90 100
LPKGEVPYFQ LAYEGLGEGY AMAGIVKDAG DDPDVTHGAT IISTVYPAPP
110 120 130 140 150
GTGIIFRAGE GVGTVTREGL AIPPPGEAAI NPVPRRMMTE ICEAICAEYG
160 170 180 190 200
LPADLVITIS VPGGEEIAQK TWNPRLGIIG GISILGTTGV VHPFSCSAWI
210 220 230 240 250
HSIHRGIDVA RAAGQKHVLG ATGSTSEDAA QALYNLPDFA ILDMGDFAGG
260 270 280 290 300
VLKYLREHPI DRLTIAGGFA KLTKLAQGAL DLHSSRSQVD KGFLWQIAER
310 320 330 340 350
AGAPADMKER ILLANTAMEV LELTQSIGID IAGPIALEAR QTALKTLRGA
360
PVEVEIIVTD RKGNILARV
Length:369
Mass (Da):38,685
Last modified:March 1, 2002 - v1
Checksum:iA46BD69E5AC6B499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL51884.1
PIRiAI3339
RefSeqiWP_004683953.1, NZ_GG703780.1

Genome annotation databases

EnsemblBacteriaiAAL51884; AAL51884; BMEI0703
GeneIDi29593502
KEGGibme:BMEI0703

Similar proteinsi

Entry informationi

Entry nameiCBID_BRUME
AccessioniPrimary (citable) accession number: Q8YHU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health