Q8YHP0 (RL3_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L3

Gene names

Name:	rplC
Ordered Locus Names:	BMEI0757

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit By similarity. HAMAP-Rule MF_01325
Subunit structure	Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19 By similarity.
Post-translational modification	Methylated by PrmB By similarity.
Sequence similarities	Belongs to the ribosomal protein L3P family.
Sequence caution	The sequence AAL51938.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Methylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	50S ribosomal protein L3 HAMAP-Rule MF_01325		PRO_0000077075
Amino acid modifications
	Modified residue	151	1	N5-methylglutamine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YHP0 [UniParc]. Last modified February 16, 2004. Version 2. Checksum: C89617EBC6E50AE5	FASTA	237	25,064
	10 20 30 40 50 60 MRSGVIAQKL GMTRVYNDAG EHVPVTVLRM ENCHVVAQRT VEKNGYTAVQ LGVGMAKVKN 70 80 90 100 110 120 TSKAMRGHFA KAEVEPKAKL AEFRVSPDNL LEVGVEITAE HFVAGQKVDV TGTSIGKGFA 130 140 150 160 170 180 GVMKRHNFGG HRASHGNSIT HRSHGSTGQR QDPGKVFKGK KMAGHMGQTR VTTQNIEVVS 190 200 210 220 230 TDSDRGLILV RGAVPGSKGA WILVRDAVKA SLPENAPKPA GLRAGAKAEA AATEGGE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51938.1. Different initiation.
PIR	AG3346.
RefSeq	NP_539674.2. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YHP0.
SMR	Q8YHP0. Positions 4-209.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0757.
Proteomic databases
PRIDE	Q8YHP0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51938; AAL51938; BMEI0757.
GeneID	1196468.
KEGG	bme:BMEI0757.
PATRIC	17851701. VBIBruMel92729_0854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000100368.
KO	K02906.
OMA	THRAHGS.
ProtClustDB	PRK00001.
Family and domain databases
HAMAP	MF_01325_B. Ribosomal_L3_B.
InterPro	IPR000597. Ribosomal_L3. IPR019927. Ribosomal_L3_bac/org-type. IPR019926. Ribosomal_L3_CS. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
PANTHER	PTHR11229. PTHR11229. 1 hit.
Pfam	PF00297. Ribosomal_L3. 1 hit. [Graphical view]
SUPFAM	SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR03625. L3_bact. 1 hit.
PROSITE	PS00474. RIBOSOMAL_L3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL3_BRUME

Accession

Primary (citable) accession number: Q8YHP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	February 16, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program