Q8YHN9 (RL4_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L4

Gene names

Name:	rplD
Ordered Locus Names:	BMEI0758

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01328_B Forms part of the polypeptide exit tunnel By similarity. HAMAP-Rule MF_01328_B
Subunit structure	Part of the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the ribosomal protein L4P family.
Sequence caution	The sequence AAL51939.1 differs from that shown. Reason: Frameshift at position 167.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	50S ribosomal protein L4 HAMAP-Rule MF_01328_B		PRO_0000129193

Sequences

	Sequence		Length	Mass (Da)
	Q8YHN9 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: 1CE73FA611BD2557	FASTA	206	22,561
	10 20 30 40 50 60 MDLTITTLEG KDAGKVKLNE EIFGLDPRDD ILQRVVRWQL ARRQQGSHKA QGRGDVSRTG 70 80 90 100 110 120 SKMYKQKGTG RARHHSARAP QFRGGGQAHG PVVRNHDHDL PKKVRALGLR HALSAKAKAS 130 140 150 160 170 180 DLIIIDDLAS ADAKTKQLVS QFAKLGLENA LLIGGAEIDA NFQRAASNIP NIDVLPVQGI 190 200 NVYDILRRGK LVLSKAAVEA LEERFK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51939.1. Frameshift.
PIR	AH3346.
RefSeq	NP_539675.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YHN9.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0758.
Proteomic databases
PRIDE	Q8YHN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51939; AAL51939; BMEI0758.
GeneID	1196469.
KEGG	bme:BMEI0758.
PATRIC	17851703. VBIBruMel92729_0855.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000248767.
KO	K02926.
ProtClustDB	PRK05319.
Family and domain databases
Gene3D	3.40.1370.10. 1 hit.
HAMAP	MF_01328_B. Ribosomal_L4_B.
InterPro	IPR002136. Ribosomal_L4/L1e. IPR013005. Ribosomal_L4/L1e_bac-type. IPR023574. Ribosomal_L4_dom. [Graphical view]
PANTHER	PTHR10746. PTHR10746. 1 hit.
Pfam	PF00573. Ribosomal_L4. 1 hit. [Graphical view]
SUPFAM	SSF52166. Ribosomal_L4/L1E. 1 hit.
TIGRFAMs	TIGR03953. rplD_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RL4_BRUME

Accession

Primary (citable) accession number: Q8YHN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program