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Q8YHH2

- CDSA_BRUME

UniProt

Q8YHH2 - CDSA_BRUME

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Protein
Phosphatidate cytidylyltransferase
Gene
cdsA, BMEI0828
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-855-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:BMEI0828
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Phosphatidate cytidylyltransferase
PRO_0000090729Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI0828.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006169.
KOiK00981.
OMAiGFILYEW.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YHH2-1 [UniParc]FASTAAdd to Basket

« Hide

MSNLQTRIIT AIVLGTITLW LTWVGGVGFT LFSIAIGLAM FYEWTELSAT    50
RQTAFSRLFG WAWLIVTGIL LILDRGALLT IGFLVAGCAI LLVTQWKSGR 100
GWPAAGLFYA GFSALSLSLL RGDEPFGFTT IVFLFAVVWS TDIAAYFNGR 150
ALGGPKLAPR FSPNKTWSGA IGGAAAAVTG GLLVASLVAA PGGWGVPVLA 200
LLLSIVSQIG DLAESWVKRQ FGAKDSGRLL PGHGGVLDRV DGLVAAAALL 250
YLFGAIFAEP DVPSAIFFSF 270
Length:270
Mass (Da):28,432
Last modified:February 7, 2006 - v2
Checksum:i2A2923106D71A723
GO

Sequence cautioni

The sequence AAL52009.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52009.1. Different initiation.
PIRiAF3355.
RefSeqiNP_539745.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52009; AAL52009; BMEI0828.
GeneIDi1196539.
KEGGibme:BMEI0828.
PATRICi17851861. VBIBruMel92729_0934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52009.1 . Different initiation.
PIRi AF3355.
RefSeqi NP_539745.1. NC_003317.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52009 ; AAL52009 ; BMEI0828 .
GeneIDi 1196539.
KEGGi bme:BMEI0828.
PATRICi 17851861. VBIBruMel92729_0934.

Phylogenomic databases

HOGENOMi HOG000006169.
KOi K00981.
OMAi GFILYEW.
OrthoDBi EOG6TBHJT.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci BMEL224914:GCJ0-855-MONOMER.

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCDSA_BRUME
AccessioniPrimary (citable) accession number: Q8YHH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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