Q8YHG6 (Q8YHG6_BRUME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycosyl transferase, family 19 EMBL EEW86757.1

Submitted name:
Lipid-a-disaccharide synthase EMBL AAL52016.1
EC=2.4.1.182 EMBL AAL52016.1

Gene names

Ordered Locus Names:	BMEI0835
ORF Names:	BAWG_2809 EMBL EEW86757.1

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL AAL52016.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8YHG6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 165F79C77921D1DE	FASTA	395	43,777
	10 20 30 40 50 60 MNETSRPLKI AIVAGEESGD LLGADLIDAL RAQTDRLVDI VGVGGDHLAE RGLKSFFDPH 70 80 90 100 110 120 EIALMGLGAI LKNLPGLMLR IRQTARQIVV EKPDCVLLID SPEFTHRVAK KIRASAPSIP 130 140 150 160 170 180 IVKYIAPSVW AWRPQRARAM RASIDHVLTV LPFEVEVMER LNGPQATYVG HRLTSHEPIL 190 200 210 220 230 240 QARASQLVLE AQRFNADKQT LLLLPGSRRT EIQMLMEPFG KAVEQLAARI EKLEVVLPTL 250 260 270 280 290 300 PRIEAMVRDL SRDWTVKPLI VTGDEEKWKA FSRADAALAA SGTVSLELAL ARIPSVLSYK 310 320 330 340 350 360 ADWFARKFLM PKITIWSAAL PNIIVDEPVV PEYFNEFVRP GMLARNLERI MRPGSARQAQ 370 380 390 LDGFDEVASV MKTEKPSGEI GARVLLALAE GRSAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.
[2]	"The Genome Sequence of Brucella melitensis bv. 1 str. 16M." The Broad Institute Genome Sequencing Platform Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Whatmore A.M., Perrett L.L., O'Callaghan D., Nusbaum C., Galagan J., Birren B. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 16M EMBL EEW86757.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52016.1. GG703780 Genomic DNA. Translation: EEW86757.1.
PIR	AE3356.
RefSeq	NP_539752.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YHG6.
ModBase	Search...
Protein-protein interaction databases
STRING	D0B9A1.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1196546.
GenomeReviews	Gene locus BMEI0835 in contig AE008917_GR.
KEGG	bme:BMEI0835.
PATRIC	17801846. VBIBruMel146950_3243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	Q8YHG6.
ProtClustDB	PRK00025.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8YHG6_BRUME

Accession

Primary (citable) accession number: Q8YHG6
Secondary accession number(s): D0B9A1

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)