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Protein

Citrate synthase

Gene

BMEI0836

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (BMEI0836)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei313UniRule annotation1
Active sitei371UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseImported, Transferase
Biological processTricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthaseUniRule annotation
Gene namesi
Ordered Locus Names:BMEI0836Imported
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)Imported
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2810

Structurei

3D structure databases

ProteinModelPortaliQ8YHG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZN Bacteria
COG0372 LUCA
HOGENOMiHOG000021224
KOiK01647
OMAiTVGWCAQ

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
IPR010953 Citrate_synthase_typ-I
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01798 cit_synth_I, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YHG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKGKTMSD KTASFTLDGK TFDLPVRKGT VGPDVVDIGP LYKNSHAFTY
60 70 80 90 100
DPGFTSTASC ESKITYIDGD EGVLLYRGYP IDQLAEHGDF LETCYLLLYG
110 120 130 140 150
ELPTATQKAD FDYRVTRHTM LHEQMTKFFT GFRRDAHPMA VMVGCLGAMS
160 170 180 190 200
AFYHDSTDIT DPHQRMVASI RLIAKVPTLA AMAYKYHIGQ PFVYPKNDLD
210 220 230 240 250
FASNFLHMCF TVPCEEYKVN PVLARAMDRI FILHADHEQN ASTSTVRLAG
260 270 280 290 300
SSGANPFACI AAGVACLWGP AHGGANEAAL NMLSEIGSVD RIPEYIARAK
310 320 330 340 350
DKNDPFRLMG FGHRVYKNYD PRAKIMQKTC HEVLGELGIK DDPLLDVAME
360 370 380 390 400
LERIALTDEY FIEKKLYPNI DFYSGITLKA LGFPTEMFTV LFALARTVGW
410 420 430
VAQWKEMIED PQQKIGRPRQ LYTGATERDY VPLAKRK
Length:437
Mass (Da):49,034
Last modified:March 1, 2002 - v1
Checksum:iFCCFF0970F123547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL52017.1
PIRiAF3356

Genome annotation databases

EnsemblBacteriaiAAL52017; AAL52017; BMEI0836
KEGGibme:BMEI0836

Similar proteinsi

Entry informationi

Entry nameiQ8YHG5_BRUME
AccessioniPrimary (citable) accession number: Q8YHG5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health