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Protein

Citrate synthase

Gene

BMEI0836

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei313 – 3131UniRule annotation
Active sitei371 – 3711UniRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthaseUniRule annotation (EC:2.3.3.16UniRule annotation)
Gene namesi
Ordered Locus Names:BMEI0836Imported
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)Imported
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI0836.

Structurei

3D structure databases

ProteinModelPortaliQ8YHG5.
SMRiQ8YHG5. Positions 12-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021224.
OMAiNKEDGVR.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YHG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKGKTMSD KTASFTLDGK TFDLPVRKGT VGPDVVDIGP LYKNSHAFTY
60 70 80 90 100
DPGFTSTASC ESKITYIDGD EGVLLYRGYP IDQLAEHGDF LETCYLLLYG
110 120 130 140 150
ELPTATQKAD FDYRVTRHTM LHEQMTKFFT GFRRDAHPMA VMVGCLGAMS
160 170 180 190 200
AFYHDSTDIT DPHQRMVASI RLIAKVPTLA AMAYKYHIGQ PFVYPKNDLD
210 220 230 240 250
FASNFLHMCF TVPCEEYKVN PVLARAMDRI FILHADHEQN ASTSTVRLAG
260 270 280 290 300
SSGANPFACI AAGVACLWGP AHGGANEAAL NMLSEIGSVD RIPEYIARAK
310 320 330 340 350
DKNDPFRLMG FGHRVYKNYD PRAKIMQKTC HEVLGELGIK DDPLLDVAME
360 370 380 390 400
LERIALTDEY FIEKKLYPNI DFYSGITLKA LGFPTEMFTV LFALARTVGW
410 420 430
VAQWKEMIED PQQKIGRPRQ LYTGATERDY VPLAKRK
Length:437
Mass (Da):49,034
Last modified:March 1, 2002 - v1
Checksum:iFCCFF0970F123547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52017.1.
PIRiAF3356.

Genome annotation databases

EnsemblBacteriaiAAL52017; AAL52017; BMEI0836.
PATRICi17851877. VBIBruMel92729_0942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52017.1.
PIRiAF3356.

3D structure databases

ProteinModelPortaliQ8YHG5.
SMRiQ8YHG5. Positions 12-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI0836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52017; AAL52017; BMEI0836.
PATRICi17851877. VBIBruMel92729_0942.

Phylogenomic databases

HOGENOMiHOG000021224.
OMAiNKEDGVR.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094Imported.

Entry informationi

Entry nameiQ8YHG5_BRUME
AccessioniPrimary (citable) accession number: Q8YHG5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.