Q8YHG5 (Q8YHG5_BRUME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Citrate synthase PIRNR PIRNR001369

Gene names

Ordered Locus Names:

BMEI0836

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP] EMBL AAL52017.1

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + H2O + oxaloacetate = citrate + CoA. SAAS SAAS002020 RuleBase RU003370
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. RuleBase RU003370
Sequence similarities	Belongs to the citrate synthase family. PIRNR PIRNR001369

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003370
Molecular function	Acyltransferase EMBL AAL52017.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	citrate (Si)-synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	313	1	By similarity PIRSR PIRSR001369-1
	Active site	371	1	By similarity PIRSR PIRSR001369-1

Sequences

	Sequence		Length	Mass (Da)
	Q8YHG5 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: FCCFF0970F123547	FASTA	437	49,034
	10 20 30 40 50 60 MDMKGKTMSD KTASFTLDGK TFDLPVRKGT VGPDVVDIGP LYKNSHAFTY DPGFTSTASC 70 80 90 100 110 120 ESKITYIDGD EGVLLYRGYP IDQLAEHGDF LETCYLLLYG ELPTATQKAD FDYRVTRHTM 130 140 150 160 170 180 LHEQMTKFFT GFRRDAHPMA VMVGCLGAMS AFYHDSTDIT DPHQRMVASI RLIAKVPTLA 190 200 210 220 230 240 AMAYKYHIGQ PFVYPKNDLD FASNFLHMCF TVPCEEYKVN PVLARAMDRI FILHADHEQN 250 260 270 280 290 300 ASTSTVRLAG SSGANPFACI AAGVACLWGP AHGGANEAAL NMLSEIGSVD RIPEYIARAK 310 320 330 340 350 360 DKNDPFRLMG FGHRVYKNYD PRAKIMQKTC HEVLGELGIK DDPLLDVAME LERIALTDEY 370 380 390 400 410 420 FIEKKLYPNI DFYSGITLKA LGFPTEMFTV LFALARTVGW VAQWKEMIED PQQKIGRPRQ 430 LYTGATERDY VPLAKRK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52017.1.
PIR	AF3356.
3D structure databases
HSSP	HSSP built from PDB template 1K3P based on UniProtKB P00891.
ProteinModelPortal	Q8YHG5.
SMR	Q8YHG5. Positions 12-436.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0836.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL52017; AAL52017; BMEI0836.
KEGG	bme:BMEI0836.
PATRIC	17851877. VBIBruMel92729_0942.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000021224.
KO	K01647.
OMA	RVTHHTM.
ProtClustDB	PRK05614.
Enzyme and pathway databases
UniPathway	UPA00223.
Family and domain databases
Gene3D	1.10.230.10. 1 hit. 1.10.580.10. 1 hit.
InterPro	IPR016142. Citrate_synth-like_lrg_a-sub. IPR016143. Citrate_synth-like_sm_a-sub. IPR002020. Citrate_synthase-like. IPR016141. Citrate_synthase-like_core. IPR019810. Citrate_synthase_AS. IPR024176. Citrate_synthase_bac-typ. IPR010953. Citrate_synthase_typ-II. [Graphical view]
PANTHER	PTHR11739. PTHR11739. 1 hit.
Pfam	PF00285. Citrate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001369. Citrate_synth. 1 hit.
PRINTS	PR00143. CITRTSNTHASE.
SUPFAM	SSF48256. Citrate_synthase_core. 1 hit.
TIGRFAMs	TIGR01798. cit_synth_I. 1 hit.
PROSITE	PS00480. CITRATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8YHG5_BRUME

Accession

Primary (citable) accession number: Q8YHG5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)