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Protein

Cyclic pyranopterin monophosphate synthase

Gene

moaC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).UniRule annotation

Catalytic activityi

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMolybdenum cofactor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic pyranopterin monophosphate synthaseUniRule annotation (EC:4.6.1.17UniRule annotation)
Alternative name(s):
Molybdenum cofactor biosynthesis protein CUniRule annotation
Gene namesi
Name:moaCUniRule annotation
Ordered Locus Names:BMEI0842
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977891 – 165Cyclic pyranopterin monophosphate synthaseAdd BLAST165

Interactioni

Subunit structurei

Homohexamer; trimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_3071.

Structurei

3D structure databases

ProteinModelPortaliQ8YHF9.
SMRiQ8YHF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 78Substrate bindingUniRule annotation3
Regioni114 – 115Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the MoaC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXW. Bacteria.
COG0315. LUCA.
HOGENOMiHOG000228417.
KOiK03637.
OMAiMCKAIDK.

Family and domain databases

CDDicd01420. MoaC_PE. 1 hit.
Gene3Di3.30.70.640. 1 hit.
HAMAPiMF_01224_B. MoaC_B. 1 hit.
InterProiView protein in InterPro
IPR023045. Mo_CF_biosynth-C.
IPR002820. Mopterin_CF_biosynth-C_dom.
PfamiView protein in Pfam
PF01967. MoaC. 1 hit.
SUPFAMiSSF55040. SSF55040. 1 hit.
TIGRFAMsiTIGR00581. moaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YHF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKLTHIDQ TGAANMVDVG SKDETERQAV AEGAVRMKPE TLALILEGNA
60 70 80 90 100
AKGDVIGTAR LAGIMAAKRT SDLIPLCHPL MLTKVAVEIE PDENLPGLRV
110 120 130 140 150
RALARLKGRT GVEMEALTAA SVTCLTIYDM AKAVDRHMEI GSIRVIEKSG
160
GKSGDWAVSD PASMR
Length:165
Mass (Da):17,480
Last modified:March 1, 2002 - v1
Checksum:iC3C97EEAAC3D96A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52023.1.
PIRiAD3357.
RefSeqiWP_004683848.1. NZ_GG703786.1.

Genome annotation databases

EnsemblBacteriaiAAL52023; AAL52023; BMEI0842.
GeneIDi29593661.
KEGGibme:BMEI0842.
bmel:DK63_578.
PATRICifig|224914.52.peg.602.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMOAC_BRUME
AccessioniPrimary (citable) accession number: Q8YHF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families