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Q8YHF2

- PYRG_BRUME

UniProt

Q8YHF2 - PYRG_BRUME

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Protein

CTP synthase

Gene
pyrG, BMEI0849
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei380 – 3801Nucleophile By similarity
Active sitei514 – 5141 By similarity
Active sitei516 – 5161 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. CTP synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase (EC:6.3.4.2)
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene namesi
Name:pyrG
Ordered Locus Names:BMEI0849
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542CTP synthaseUniRule annotationPRO_0000138167Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0849.

Structurei

3D structure databases

ProteinModelPortaliQ8YHF2.
SMRiQ8YHF2. Positions 2-540.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini291 – 541251Glutamine amidotransferase type-1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 252252Aminator domainUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000077515.
KOiK01937.
OMAiYWNVISK.
OrthoDBiEOG6RC3NR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YHF2-1 [UniParc]FASTAAdd to Basket

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MARYVFITGG VVSSLGKGIA AAALAALLQA RGYRVRIRKL DPYLNVDPGT    50
MSPYQHGEVF VTDDGAETDL DLGHYERFTG RPANQQDNIT TGRIYRNIIE 100
KERRGDYLGA TVQVIPHVTD EIKNFVLEGN EDYDFVLCEI GGTVGDIEAM 150
PFLEAIRQLG NELPRGTAVY IHLTLMPYIP AAGELKTKPT QHSVKELRSI 200
GIAPDILLVR ADREIPESER RKLSLFCNVR ESAVIQALDV ATIYDVPIAY 250
HKEGLDSEVL SAFGIDPAPK PRMDRWEEVS HRLHNPEGEV TIAVVGKYTG 300
LKDAYKSLIE ALHHGGLANK VKVNLDWIEA EVFESEDPAP YLEKVHGILV 350
PGGFGERGAE GKILAAKFAR ERKVPYFGIC FGMQMACIEA ARNLVGIEDA 400
SSSEFDPTRE PVVGLMTEWL KGNMLEKRAA AGDLGGTMRL GAYEAVLKPD 450
SKIAQIYGST DIHERHRHRY EVNIDYKDRL EAAGLNFAGM SPDGVLPETV 500
EYADHPWFIG VQYHPELKSR PFEPHPLFAS FIEAAIEQSR LV 542
Length:542
Mass (Da):60,135
Last modified:March 1, 2002 - v1
Checksum:i30FE1EB1F908493E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52030.1.
PIRiAC3358.
RefSeqiNP_539766.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52030; AAL52030; BMEI0849.
GeneIDi1196560.
KEGGibme:BMEI0849.
PATRICi17801877. VBIBruMel146950_3258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52030.1 .
PIRi AC3358.
RefSeqi NP_539766.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YHF2.
SMRi Q8YHF2. Positions 2-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52030 ; AAL52030 ; BMEI0849 .
GeneIDi 1196560.
KEGGi bme:BMEI0849.
PATRICi 17801877. VBIBruMel146950_3258.

Phylogenomic databases

HOGENOMi HOG000077515.
KOi K01937.
OMAi YWNVISK.
OrthoDBi EOG6RC3NR.

Enzyme and pathway databases

UniPathwayi UPA00159 ; UER00277 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_01227. PyrG.
InterProi IPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11550. PTHR11550. 1 hit.
Pfami PF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00337. PyrG. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiPYRG_BRUME
AccessioniPrimary (citable) accession number: Q8YHF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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