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Q8YHC7

- CLPX_BRUME

UniProt

Q8YHC7 - CLPX_BRUME

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Protein
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene
clpX, BMEI0875
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 4226C4-typeUniRule annotation
Add
BLAST
Nucleotide bindingi121 – 1288ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. nucleoside-triphosphatase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene namesi
Name:clpX
Ordered Locus Names:BMEI0875
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
PRO_0000160326Add
BLAST

Proteomic databases

PRIDEiQ8YHC7.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi224914.BMEI0875.

Structurei

3D structure databases

ProteinModelPortaliQ8YHC7.
SMRiQ8YHC7. Positions 11-53.

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000010093.
KOiK03544.
OMAiKLFSMEG.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YHC7-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVSNGGGD SKNTLYCSFC GKSQHEVRKL IAGPTVFICD ECVELCMDII    50
REENKSSMVK SREGVPTPQE IMAVLDDYVI GQKDAKRVLS VAVHNHYKRL 100
AHQSKNSDIE LAKSNILLVG PTGCGKTYLA QTLARIIDVP FIMADATTLT 150
EAGYVGEDVE NIILKLLQAA DYNVERAQRG IVYIDEVDKI SRKSDNPSIT 200
RDVSGEGVQQ ALLKIMEGTV ASVPPQGGRK HPQQEFLQVD TTNILFICGG 250
AFAGLDRIIS ARGEKTSIGF GATVKSVDER RIGEVFKELE PEDLLKFGLI 300
PEFVGRLPVI ATLEDLDVDA LVQILTEPKN ALVKQYQRLF DMENVELVFH 350
DDALRAIANK AVERKTGARG LRSIMEKILL DTMFELPTLE GVREVVISGD 400
VVDGSARPLY IYAERQDEKG NVSA 424
Length:424
Mass (Da):46,656
Last modified:March 1, 2002 - v1
Checksum:i6A68089A37209608
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52056.1.
PIRiAE3361.
RefSeqiNP_539792.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52056; AAL52056; BMEI0875.
GeneIDi1196586.
KEGGibme:BMEI0875.
PATRICi17801934. VBIBruMel146950_3287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52056.1 .
PIRi AE3361.
RefSeqi NP_539792.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YHC7.
SMRi Q8YHC7. Positions 11-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0875.

Proteomic databases

PRIDEi Q8YHC7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52056 ; AAL52056 ; BMEI0875 .
GeneIDi 1196586.
KEGGi bme:BMEI0875.
PATRICi 17801934. VBIBruMel146950_3287.

Phylogenomic databases

HOGENOMi HOG000010093.
KOi K03544.
OMAi KLFSMEG.
OrthoDBi EOG625JZK.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00175. ClpX.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view ]
Pfami PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00382. clpX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiCLPX_BRUME
AccessioniPrimary (citable) accession number: Q8YHC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi