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Q8YH64 (XGPT_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xanthine phosphoribosyltransferase

EC=2.4.2.22
Alternative name(s):
Xanthine-guanine phosphoribosyltransferase
Short name=XGPRT
Gene names
Name:gpt
Ordered Locus Names:BMEI0940
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts on guanine, xanthine and to a lesser extent hypoxanthine By similarity. HAMAP-Rule MF_01903

Catalytic activity

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01903

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01903

Pathway

Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01903

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01903

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01903.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandMagnesium
Metal-binding
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processXMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Xanthine phosphoribosyltransferase HAMAP-Rule MF_01903
PRO_0000139658

Regions

Region41 – 4225-phosphoribose 1-diphosphate binding By similarity
Region102 – 10655-phosphoribose 1-diphosphate binding By similarity

Sites

Metal binding991Magnesium By similarity
Binding site1021Xanthine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YH64 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: EB7D688B3D45A169

FASTA17018,821
        10         20         30         40         50         60 
MSLPDKAFPV SWDQFHRDAR ALAWRIAGLD REWRAIVAIT RGGLVPAAII CRELGIRLIE 

        70         80         90        100        110        120 
TVCIASYHDY TSQGEMQVLK GIGASLLENQ GEGVIVVDDL TDTGKTAAIV REMMPRAHFA 

       130        140        150        160        170 
TVYAKPKGRP LIDTLRHGGL TGYLDLFPMG YGLHLSGADC WRKTRLNETK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52121.1.
PIRAF3369.
RefSeqNP_539857.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YH64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI0940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52121; AAL52121; BMEI0940.
GeneID1196651.
KEGGbme:BMEI0940.
PATRIC17798188. VBIBruMel146950_0955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000226805.
KOK00769.
OMAFPWDMGL.
OrthoDBEOG6H1Q23.

Enzyme and pathway databases

UniPathwayUPA00602; UER00658.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01903. XGPRT.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
ProtoNetSearch...

Entry information

Entry nameXGPT_BRUME
AccessionPrimary (citable) accession number: Q8YH64
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names