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Q8YH64

- XGPT_BRUME

UniProt

Q8YH64 - XGPT_BRUME

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Protein

Xanthine phosphoribosyltransferase

Gene
gpt, BMEI0940
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine By similarity.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991Magnesium By similarity
Binding sitei102 – 1021Xanthine By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
  2. XMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferase (EC:2.4.2.22)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferase
Short name:
XGPRT
Gene namesi
Name:gpt
Ordered Locus Names:BMEI0940
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Xanthine phosphoribosyltransferaseUniRule annotationPRO_0000139658Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI0940.

Structurei

3D structure databases

ProteinModelPortaliQ8YH64.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 4225-phosphoribose 1-diphosphate binding By similarity
Regioni102 – 10655-phosphoribose 1-diphosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000226805.
KOiK00769.
OMAiFPWDMGL.
OrthoDBiEOG6H1Q23.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01903. XGPRT.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YH64-1 [UniParc]FASTAAdd to Basket

« Hide

MSLPDKAFPV SWDQFHRDAR ALAWRIAGLD REWRAIVAIT RGGLVPAAII    50
CRELGIRLIE TVCIASYHDY TSQGEMQVLK GIGASLLENQ GEGVIVVDDL 100
TDTGKTAAIV REMMPRAHFA TVYAKPKGRP LIDTLRHGGL TGYLDLFPMG 150
YGLHLSGADC WRKTRLNETK 170
Length:170
Mass (Da):18,821
Last modified:March 1, 2002 - v1
Checksum:iEB7D688B3D45A169
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52121.1.
PIRiAF3369.
RefSeqiNP_539857.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52121; AAL52121; BMEI0940.
GeneIDi1196651.
KEGGibme:BMEI0940.
PATRICi17798188. VBIBruMel146950_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52121.1 .
PIRi AF3369.
RefSeqi NP_539857.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YH64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI0940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52121 ; AAL52121 ; BMEI0940 .
GeneIDi 1196651.
KEGGi bme:BMEI0940.
PATRICi 17798188. VBIBruMel146950_0955.

Phylogenomic databases

HOGENOMi HOG000226805.
KOi K00769.
OMAi FPWDMGL.
OrthoDBi EOG6H1Q23.

Enzyme and pathway databases

UniPathwayi UPA00602 ; UER00658 .

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01903. XGPRT.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiXGPT_BRUME
AccessioniPrimary (citable) accession number: Q8YH64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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