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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei102XanthineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:BMEI0940
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396581 – 170Xanthine phosphoribosyltransferaseAdd BLAST170

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_1264

Structurei

3D structure databases

ProteinModelPortaliQ8YH64
SMRiQ8YH64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 425-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni102 – 1065-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503 LUCA
HOGENOMiHOG000226805
KOiK00769

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01903 XGPRT, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023747 Xanthine_Guanine_PRibTrfase
PANTHERiPTHR39563 PTHR39563, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YH64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPDKAFPV SWDQFHRDAR ALAWRIAGLD REWRAIVAIT RGGLVPAAII
60 70 80 90 100
CRELGIRLIE TVCIASYHDY TSQGEMQVLK GIGASLLENQ GEGVIVVDDL
110 120 130 140 150
TDTGKTAAIV REMMPRAHFA TVYAKPKGRP LIDTLRHGGL TGYLDLFPMG
160 170
YGLHLSGADC WRKTRLNETK
Length:170
Mass (Da):18,821
Last modified:March 1, 2002 - v1
Checksum:iEB7D688B3D45A169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL52121.1
PIRiAF3369

Genome annotation databases

EnsemblBacteriaiAAL52121; AAL52121; BMEI0940
KEGGibme:BMEI0940
bmel:DK63_482
PATRICifig|224914.52.peg.504

Similar proteinsi

Entry informationi

Entry nameiXGPT_BRUME
AccessioniPrimary (citable) accession number: Q8YH64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health