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Q8YH64

- XGPT_BRUME

UniProt

Q8YH64 - XGPT_BRUME

Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

    Catalytic activityi

    XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991MagnesiumUniRule annotation
    Binding sitei102 – 1021XanthineUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
    2. XMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00602; UER00658.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
    Alternative name(s):
    Xanthine-guanine phosphoribosyltransferaseUniRule annotation
    Short name:
    XGPRTUniRule annotation
    Gene namesi
    Name:gptUniRule annotation
    Ordered Locus Names:BMEI0940
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Xanthine phosphoribosyltransferasePRO_0000139658Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI0940.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YH64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 4225-phosphoribose 1-diphosphate bindingUniRule annotation
    Regioni102 – 10655-phosphoribose 1-diphosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000226805.
    KOiK00769.
    OMAiFPWDMGL.
    OrthoDBiEOG6H1Q23.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01903. XGPRT.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023747. Xanthine_Guanine_PRibTrfase.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YH64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPDKAFPV SWDQFHRDAR ALAWRIAGLD REWRAIVAIT RGGLVPAAII    50
    CRELGIRLIE TVCIASYHDY TSQGEMQVLK GIGASLLENQ GEGVIVVDDL 100
    TDTGKTAAIV REMMPRAHFA TVYAKPKGRP LIDTLRHGGL TGYLDLFPMG 150
    YGLHLSGADC WRKTRLNETK 170
    Length:170
    Mass (Da):18,821
    Last modified:March 1, 2002 - v1
    Checksum:iEB7D688B3D45A169
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52121.1.
    PIRiAF3369.
    RefSeqiNP_539857.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52121; AAL52121; BMEI0940.
    GeneIDi1196651.
    KEGGibme:BMEI0940.
    PATRICi17798188. VBIBruMel146950_0955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52121.1 .
    PIRi AF3369.
    RefSeqi NP_539857.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YH64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI0940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52121 ; AAL52121 ; BMEI0940 .
    GeneIDi 1196651.
    KEGGi bme:BMEI0940.
    PATRICi 17798188. VBIBruMel146950_0955.

    Phylogenomic databases

    HOGENOMi HOG000226805.
    KOi K00769.
    OMAi FPWDMGL.
    OrthoDBi EOG6H1Q23.

    Enzyme and pathway databases

    UniPathwayi UPA00602 ; UER00658 .

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01903. XGPRT.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023747. Xanthine_Guanine_PRibTrfase.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiXGPT_BRUME
    AccessioniPrimary (citable) accession number: Q8YH64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3