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Protein

Thymidylate kinase

Gene

tmk

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:BMEI0989
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552471 – 214Thymidylate kinaseAdd BLAST214

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1215.

Structurei

3D structure databases

ProteinModelPortaliQ8YH15.
SMRiQ8YH15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
KOiK00943.
OMAiFLYTADH.

Family and domain databases

HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiView protein in PROSITE
PS01331. THYMIDYLATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YH15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLFITFEG GEGAGKSTQI ALLASHLRNH GFDPVITREP GGSPGAEAIR
60 70 80 90 100
HVILSGNAET YGPAMEALLF AAARADHVDQ LIRPTLAEGR IVLCDRFIDS
110 120 130 140 150
SRAYQGVTGN LDATYMAAIE RIAIDGAMPD LTLVLDICAE RGLSRAGKRR
160 170 180 190 200
GSDTADRFEK EDIAVHEARR QAFLEIARQE PARCKVIDAD RSQEKIADEI
210
RSVVDTILTE KGLL
Length:214
Mass (Da):23,171
Last modified:March 1, 2002 - v1
Checksum:i8A41ED033DF02E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52170.1.
PIRiAG3375.
RefSeqiWP_002964110.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52170; AAL52170; BMEI0989.
GeneIDi29593810.
KEGGibme:BMEI0989.
bmel:DK63_432.
PATRICifig|224914.52.peg.450.

Similar proteinsi

Entry informationi

Entry nameiKTHY_BRUME
AccessioniPrimary (citable) accession number: Q8YH15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families