Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8YGW9

- NADK_BRUME

UniProt

Q8YGW9 - NADK_BRUME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptorUniRule annotation
Binding sitei146 – 1461NADUniRule annotation
Binding sitei154 – 1541NAD; via carbonyl oxygenUniRule annotation
Binding sitei218 – 2181NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 472NADUniRule annotation
Nucleotide bindingi116 – 1172NADUniRule annotation
Nucleotide bindingi157 – 1626NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BMEI1036
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257NAD kinasePRO_0000120603Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1036.

Structurei

3D structure databases

ProteinModelPortaliQ8YGW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YGW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDTSLALHF VSSGTKESLS AQKDLVERYG HVAAEDADII VALGGDGTML
60 70 80 90 100
QALRDFMNTG KPIYGMNRGS VGFLMNEFVI ENLPERILAA QMETIRPLVM
110 120 130 140 150
VAETDDAPPV EALAINEVSL FRQSYQAARI RITIDGKVRL QELVCDGVMV
160 170 180 190 200
ATPAGSTAYN LSAQGPILPL EAPLLALTPV SPFRPRRWGG ALLPKHVTVR
210 220 230 240 250
MDLLETEKRP VNAVADNNEV KSVTSVTVRE APNSQVTILF DKNHSWDERI

LTEQFRH
Length:257
Mass (Da):28,261
Last modified:October 25, 2002 - v2
Checksum:i4EA7A24F2404F65A
GO

Sequence cautioni

The sequence AAL52217.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52217.1. Different initiation.
PIRiAF3381.
RefSeqiNP_539953.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52217; AAL52217; BMEI1036.
GeneIDi1196747.
KEGGibme:BMEI1036.
PATRICi17852327. VBIBruMel92729_1160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52217.1 . Different initiation.
PIRi AF3381.
RefSeqi NP_539953.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YGW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52217 ; AAL52217 ; BMEI1036 .
GeneIDi 1196747.
KEGGi bme:BMEI1036.
PATRICi 17852327. VBIBruMel92729_1160.

Phylogenomic databases

HOGENOMi HOG000139847.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-1069-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiNADK_BRUME
AccessioniPrimary (citable) accession number: Q8YGW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: November 26, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3