Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8YGW9

- NADK_BRUME

UniProt

Q8YGW9 - NADK_BRUME

Protein

NAD kinase

Gene

nadK

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptorUniRule annotation
    Binding sitei146 – 1461NADUniRule annotation
    Binding sitei154 – 1541NAD; via carbonyl oxygenUniRule annotation
    Binding sitei218 – 2181NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 472NADUniRule annotation
    Nucleotide bindingi116 – 1172NADUniRule annotation
    Nucleotide bindingi157 – 1626NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-1069-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:BMEI1036
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257NAD kinasePRO_0000120603Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI1036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YGW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000139847.
    KOiK00858.
    OMAiHESTVSI.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YGW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDTSLALHF VSSGTKESLS AQKDLVERYG HVAAEDADII VALGGDGTML    50
    QALRDFMNTG KPIYGMNRGS VGFLMNEFVI ENLPERILAA QMETIRPLVM 100
    VAETDDAPPV EALAINEVSL FRQSYQAARI RITIDGKVRL QELVCDGVMV 150
    ATPAGSTAYN LSAQGPILPL EAPLLALTPV SPFRPRRWGG ALLPKHVTVR 200
    MDLLETEKRP VNAVADNNEV KSVTSVTVRE APNSQVTILF DKNHSWDERI 250
    LTEQFRH 257
    Length:257
    Mass (Da):28,261
    Last modified:October 25, 2002 - v2
    Checksum:i4EA7A24F2404F65A
    GO

    Sequence cautioni

    The sequence AAL52217.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52217.1. Different initiation.
    PIRiAF3381.
    RefSeqiNP_539953.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52217; AAL52217; BMEI1036.
    GeneIDi1196747.
    KEGGibme:BMEI1036.
    PATRICi17852327. VBIBruMel92729_1160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52217.1 . Different initiation.
    PIRi AF3381.
    RefSeqi NP_539953.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YGW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52217 ; AAL52217 ; BMEI1036 .
    GeneIDi 1196747.
    KEGGi bme:BMEI1036.
    PATRICi 17852327. VBIBruMel92729_1160.

    Phylogenomic databases

    HOGENOMi HOG000139847.
    KOi K00858.
    OMAi HESTVSI.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci BMEL224914:GCJ0-1069-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiNADK_BRUME
    AccessioniPrimary (citable) accession number: Q8YGW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3