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Protein

Trigger factor

Gene

tig

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factor (EC:5.2.1.8)
Short name:
TF
Alternative name(s):
PPIase
Gene namesi
Name:tig
Ordered Locus Names:BMEI1069
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

Q8YGT8:
  • Cytoplasm
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001793241 – 477Trigger factorAdd BLAST477

Proteomic databases

PRIDEiQ8YGT8.

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1140.

Structurei

3D structure databases

ProteinModelPortaliQ8YGT8.
SMRiQ8YGT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 254PPIase FKBP-typeAdd BLAST86

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105DEA. Bacteria.
COG0544. LUCA.
HOGENOMiHOG000218241.
KOiK03545.
OMAiMAMIEDR.

Family and domain databases

Gene3Di3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiView protein in InterPro
IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR036611. Trigger_fac_ribosome-bd_sf.
IPR027304. Trigger_fact/SurA_dom.
PANTHERiPTHR30560. PTHR30560. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YGT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVTETLNEG LKREIKVVVP AGDLEAKLAE RLETARGRAR INGFRPGKVP
60 70 80 90 100
TAHLRKMYGK SFMAEIVNEI LNDSSRSILA ERNEKSATQP EVIMSEDEKE
110 120 130 140 150
AEKVLDGKAD FVFSLNYEVL PAIEVKDFSK IAVTREVVDI SDEEVDEQVK
160 170 180 190 200
RIASSTRTFE TKKGKAENED RVTIDYLGKL DGEPFEGGAD NDAQLVLGSG
210 220 230 240 250
QFIPGFEEQL IGLKAGDEKV ITVTFPAEYG AAHLAGKEAT FDIKVKEVAK
260 270 280 290 300
PNELVLDDET AKKLGIESLE RLRQVVREQI ESQYGQITRQ KVKRQILDAL
310 320 330 340 350
DGDYQFETPQ KLVDAEFNNI WQQINFDLQQ AGRTFEDEET TEEAAREEYR
360 370 380 390 400
KLAERRVRLG LVLSEIGEKA GVEVTEEELQ RAVYDQVRRY PGQEKEIYDF
410 420 430 440 450
LRRTPDAVAN LRAPIFEEKV VDHLLANINV TDKKVSKEEL TAEDEDAASE
460 470
AKPAKKAAAK KKAAPKKKAE EGKSEEA
Length:477
Mass (Da):53,561
Last modified:May 27, 2002 - v2
Checksum:i3EF7502661711C15
GO

Sequence cautioni

Q8YGT8: The sequence AAL52250 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52250.1. Different initiation.
PIRiAG3385.

Genome annotation databases

EnsemblBacteriaiAAL52250; AAL52250; BMEI1069.
KEGGibme:BMEI1069.
bmel:DK63_345.
PATRICifig|224914.52.peg.357.

Similar proteinsi

Entry informationi

Entry nameiTIG_BRUME
AccessioniPrimary (citable) accession number: Q8YGT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: October 25, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families