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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (BMEI1117)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:BMEI1122
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001008091 – 254Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST254

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1087.

Structurei

3D structure databases

ProteinModelPortaliQ8YGN6.
SMRiQ8YGN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Family and domain databases

CDDicd01415. SAICAR_synt_PurC. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiView protein in InterPro
IPR028923. SAICAR_synt/ADE2_N.
IPR033934. SAICAR_synt_PurC.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
PfamiView protein in Pfam
PF01259. SAICAR_synt. 1 hit.
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiView protein in PROSITE
PS01057. SAICAR_SYNTHETASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YGN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRRRRIYEG KAKILYEGPE PGTLVQFFKD DATAFNAKKH EVIDGKGVLN
60 70 80 90 100
NRISEHIFTQ LNRIGIPTHF IRRLNMREQL IKEVEIIPLE VVVRNVAAGS
110 120 130 140 150
LAKHLGLEEG TILPRSIIEF YYKADALDDP MVTEEHITAF GWASPQEIDD
160 170 180 190 200
IMALAIRVND FLTGLFLGIG IQLVDFKMEC GRLWEGDMMR IVVADEISPD
210 220 230 240 250
SARLWDITTN DKLDKDRFRR DMGGLVEAYQ EVARRLGIMN ENDTPRPSGP

TLVK
Length:254
Mass (Da):28,937
Last modified:March 1, 2002 - v1
Checksum:i0E49FF97B47F88DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52303.1.
PIRiAD3392.
RefSeqiWP_002963974.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52303; AAL52303; BMEI1122.
GeneIDi29593967.
KEGGibme:BMEI1122.
bmel:DK63_292.
PATRICifig|224914.52.peg.301.

Similar proteinsi

Entry informationi

Entry nameiPUR7_BRUME
AccessioniPrimary (citable) accession number: Q8YGN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families