Q8YGM0 (LOLD_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein-releasing system ATP-binding protein LolD
EC=3.6.3.-

Gene names

Name:	lolD
Ordered Locus Names:	BMEI1138

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification] Contains 1 ABC transporter domain.
Sequence caution	The sequence AAL52319.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro lipoprotein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Lipoprotein-releasing system ATP-binding protein LolD		PRO_0000092423
Regions
	Domain	7 – 227	221	ABC transporter
	Nucleotide binding	43 – 50	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YGM0 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: E49DCFD20A3462C3	FASTA	227	24,930
	10 20 30 40 50 60 MAAEIILRLE RIGRAYKEAD RELIILNDAD FTLRRGEMVA LVAPSGAGKS TLLHTAGLLE 70 80 90 100 110 120 RPDSGDVVLD GRSCSKLSDD ERTAVRRNDV GFVYQFHHLL PEFSALENVM LPQMIRGLSR 130 140 150 160 170 180 KAAAERAQQL LEYMKIGKRA SHRPAELSGG EQQRVAIARA VANAPLVLLA DEPTGNLDPT 190 200 210 220 TSSYVFGALE ALVRQSGLAA LIATHNHELA RRMDRRVTLK DGRVVDL

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52319.1. Different initiation.
PIR	AD3394.
RefSeq	NP_540055.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YGM0.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI1138.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL52319; AAL52319; BMEI1138.
GeneID	1196849.
KEGG	bme:BMEI1138.
PATRIC	17852557. VBIBruMel92729_1273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K09810.
OMA	ATHNFEL.
ProtClustDB	CLSK863251.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015854. ABC_transpr_LolD. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51244. LOLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LOLD_BRUME

Accession

Primary (citable) accession number: Q8YGM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program