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Q8YGK3

- NUOD_BRUME

UniProt

Q8YGK3 - NUOD_BRUME

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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:BMEI1155
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396NADH-quinone oxidoreductase subunit DPRO_0000357786Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI1155.

Structurei

3D structure databases

ProteinModelPortaliQ8YGK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228264.
KOiK00333.
OMAiWRIREKI.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YGK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAETQVRNFN INFGPQHPAA HGVLRLVLEL DGEVVERVDP HIGLLHRGTE
60 70 80 90 100
KLMEAKTYLQ AVPYLDRLDY VAPMNQEHAY ALAVERLLDI EVPKRGQLIR
110 120 130 140 150
VLYSEIGRIL NHLLNVTTQA MDVGALTPPL WGFEEREKLM VFYERACGAR
160 170 180 190 200
MHAAYFRPGG VHQDLPDQLI EDIGKWIDPF FTTLKNLDDL ITPNRIFKQR
210 220 230 240 250
NVDIGVVKLE DAWAWGFSGV MVRGSGAAWD LRKSQPYECY SEMEFDIPVG
260 270 280 290 300
KNGDCYDRYL IRMEEMRQSV RIMRQCVDLL LGKERVGPVS NTDHKIVPPK
310 320 330 340 350
RGEMKRSMEA LIHHFKLYTE GYHVPAGEVY AAVEAPKGEF GVYLVSDGSN
360 370 380 390
KPYRCKLRAP GFAHLQAMDF LCRGHMLADV SAILGSLDIV FGEVDR
Length:396
Mass (Da):45,011
Last modified:March 1, 2002 - v1
Checksum:iAF24D18216459F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52336.1.
PIRiAE3396.
RefSeqiNP_540072.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52336; AAL52336; BMEI1155.
GeneIDi1196866.
KEGGibme:BMEI1155.
PATRICi17797708. VBIBruMel146950_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52336.1 .
PIRi AE3396.
RefSeqi NP_540072.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YGK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52336 ; AAL52336 ; BMEI1155 .
GeneIDi 1196866.
KEGGi bme:BMEI1155.
PATRICi 17797708. VBIBruMel146950_0669.

Phylogenomic databases

HOGENOMi HOG000228264.
KOi K00333.
OMAi WRIREKI.
OrthoDBi EOG62G5MP.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiNUOD_BRUME
AccessioniPrimary (citable) accession number: Q8YGK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3