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Q8YGK3

- NUOD_BRUME

UniProt

Q8YGK3 - NUOD_BRUME

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Protein
NADH-quinone oxidoreductase subunit D
Gene
nuoD, BMEI1155
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit D (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene namesi
Name:nuoD
Ordered Locus Names:BMEI1155
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396NADH-quinone oxidoreductase subunit DUniRule annotation
PRO_0000357786Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi224914.BMEI1155.

Structurei

3D structure databases

ProteinModelPortaliQ8YGK3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228264.
KOiK00333.
OMAiWRIREKI.
OrthoDBiEOG62G5MP.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YGK3-1 [UniParc]FASTAAdd to Basket

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MAETQVRNFN INFGPQHPAA HGVLRLVLEL DGEVVERVDP HIGLLHRGTE    50
KLMEAKTYLQ AVPYLDRLDY VAPMNQEHAY ALAVERLLDI EVPKRGQLIR 100
VLYSEIGRIL NHLLNVTTQA MDVGALTPPL WGFEEREKLM VFYERACGAR 150
MHAAYFRPGG VHQDLPDQLI EDIGKWIDPF FTTLKNLDDL ITPNRIFKQR 200
NVDIGVVKLE DAWAWGFSGV MVRGSGAAWD LRKSQPYECY SEMEFDIPVG 250
KNGDCYDRYL IRMEEMRQSV RIMRQCVDLL LGKERVGPVS NTDHKIVPPK 300
RGEMKRSMEA LIHHFKLYTE GYHVPAGEVY AAVEAPKGEF GVYLVSDGSN 350
KPYRCKLRAP GFAHLQAMDF LCRGHMLADV SAILGSLDIV FGEVDR 396
Length:396
Mass (Da):45,011
Last modified:March 1, 2002 - v1
Checksum:iAF24D18216459F0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52336.1.
PIRiAE3396.
RefSeqiNP_540072.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52336; AAL52336; BMEI1155.
GeneIDi1196866.
KEGGibme:BMEI1155.
PATRICi17797708. VBIBruMel146950_0669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52336.1 .
PIRi AE3396.
RefSeqi NP_540072.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YGK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52336 ; AAL52336 ; BMEI1155 .
GeneIDi 1196866.
KEGGi bme:BMEI1155.
PATRICi 17797708. VBIBruMel146950_0669.

Phylogenomic databases

HOGENOMi HOG000228264.
KOi K00333.
OMAi WRIREKI.
OrthoDBi EOG62G5MP.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiNUOD_BRUME
AccessioniPrimary (citable) accession number: Q8YGK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi