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Q8YGK3

- NUOD_BRUME

UniProt

Q8YGK3 - NUOD_BRUME

Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    3. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit DUniRule annotation
    NDH-1 subunit DUniRule annotation
    Gene namesi
    Name:nuoDUniRule annotation
    Ordered Locus Names:BMEI1155
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396NADH-quinone oxidoreductase subunit DPRO_0000357786Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI1155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YGK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228264.
    KOiK00333.
    OMAiWRIREKI.
    OrthoDBiEOG62G5MP.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YGK3-1 [UniParc]FASTAAdd to Basket

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    MAETQVRNFN INFGPQHPAA HGVLRLVLEL DGEVVERVDP HIGLLHRGTE    50
    KLMEAKTYLQ AVPYLDRLDY VAPMNQEHAY ALAVERLLDI EVPKRGQLIR 100
    VLYSEIGRIL NHLLNVTTQA MDVGALTPPL WGFEEREKLM VFYERACGAR 150
    MHAAYFRPGG VHQDLPDQLI EDIGKWIDPF FTTLKNLDDL ITPNRIFKQR 200
    NVDIGVVKLE DAWAWGFSGV MVRGSGAAWD LRKSQPYECY SEMEFDIPVG 250
    KNGDCYDRYL IRMEEMRQSV RIMRQCVDLL LGKERVGPVS NTDHKIVPPK 300
    RGEMKRSMEA LIHHFKLYTE GYHVPAGEVY AAVEAPKGEF GVYLVSDGSN 350
    KPYRCKLRAP GFAHLQAMDF LCRGHMLADV SAILGSLDIV FGEVDR 396
    Length:396
    Mass (Da):45,011
    Last modified:March 1, 2002 - v1
    Checksum:iAF24D18216459F0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52336.1.
    PIRiAE3396.
    RefSeqiNP_540072.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52336; AAL52336; BMEI1155.
    GeneIDi1196866.
    KEGGibme:BMEI1155.
    PATRICi17797708. VBIBruMel146950_0669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52336.1 .
    PIRi AE3396.
    RefSeqi NP_540072.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YGK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52336 ; AAL52336 ; BMEI1155 .
    GeneIDi 1196866.
    KEGGi bme:BMEI1155.
    PATRICi 17797708. VBIBruMel146950_0669.

    Phylogenomic databases

    HOGENOMi HOG000228264.
    KOi K00333.
    OMAi WRIREKI.
    OrthoDBi EOG62G5MP.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiNUOD_BRUME
    AccessioniPrimary (citable) accession number: Q8YGK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3