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Q8YGK3 (NUOD_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene names
Name:nuoD
Ordered Locus Names:BMEI1155
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01358

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396NADH-quinone oxidoreductase subunit D HAMAP-Rule MF_01358
PRO_0000357786

Sequences

Sequence LengthMass (Da)Tools
Q8YGK3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: AF24D18216459F0D

FASTA39645,011
        10         20         30         40         50         60 
MAETQVRNFN INFGPQHPAA HGVLRLVLEL DGEVVERVDP HIGLLHRGTE KLMEAKTYLQ 

        70         80         90        100        110        120 
AVPYLDRLDY VAPMNQEHAY ALAVERLLDI EVPKRGQLIR VLYSEIGRIL NHLLNVTTQA 

       130        140        150        160        170        180 
MDVGALTPPL WGFEEREKLM VFYERACGAR MHAAYFRPGG VHQDLPDQLI EDIGKWIDPF 

       190        200        210        220        230        240 
FTTLKNLDDL ITPNRIFKQR NVDIGVVKLE DAWAWGFSGV MVRGSGAAWD LRKSQPYECY 

       250        260        270        280        290        300 
SEMEFDIPVG KNGDCYDRYL IRMEEMRQSV RIMRQCVDLL LGKERVGPVS NTDHKIVPPK 

       310        320        330        340        350        360 
RGEMKRSMEA LIHHFKLYTE GYHVPAGEVY AAVEAPKGEF GVYLVSDGSN KPYRCKLRAP 

       370        380        390 
GFAHLQAMDF LCRGHMLADV SAILGSLDIV FGEVDR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52336.1.
PIRAE3396.
RefSeqNP_540072.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YGK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52336; AAL52336; BMEI1155.
GeneID1196866.
KEGGbme:BMEI1155.
PATRIC17797708. VBIBruMel146950_0669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228264.
KOK00333.
OMAEYRTWTQ.
OrthoDBEOG62G5MP.
ProtClustDBPRK06075.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOD_BRUME
AccessionPrimary (citable) accession number: Q8YGK3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names