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Protein

NADH-quinone oxidoreductase subunit C

Gene

nuoC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit CUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit CUniRule annotation
NDH-1 subunit CUniRule annotation
Gene namesi
Name:nuoCUniRule annotation
Ordered Locus Names:BMEI1156
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003580541 – 202NADH-quinone oxidoreductase subunit CAdd BLAST202

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_1053

Structurei

3D structure databases

ProteinModelPortaliQ8YGK2
SMRiQ8YGK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CYU Bacteria
COG0852 LUCA
HOGENOMiHOG000009797
KOiK00332
OMAiVFPAANW

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR020396 NADH_UbQ_OxRdtase_CS
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
TIGRFAMsiTIGR01961 NuoC_fam, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEALGELS GYIRERLGDA IEEANLAYGE LTLCVPVASL IGVLTFLRDD
60 70 80 90 100
VQCQFVNLTD ISGVDYPQRE KRFDVVYQLL SPRQNQRIRV KVQADEDTLV
110 120 130 140 150
PSAVPVFFGA EWYEREAYDM YGILFSGHPD LRRILTDYGF EGHPLRKDFP
160 170 180 190 200
LTGFVEVRYN DELKRVVYEP VQLRQEFRNF DFLSPWEGTD YVLPGDEKAK

TN
Length:202
Mass (Da):23,343
Last modified:March 1, 2002 - v1
Checksum:i70A73C371CEFA84C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL52337.1
PIRiAF3396
RefSeqiWP_002967574.1, NZ_GG703778.1

Genome annotation databases

EnsemblBacteriaiAAL52337; AAL52337; BMEI1156
GeneIDi29593998
KEGGibme:BMEI1156
bmel:DK63_257
PATRICifig|224914.52.peg.266

Similar proteinsi

Entry informationi

Entry nameiNUOC_BRUME
AccessioniPrimary (citable) accession number: Q8YGK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health