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Q8YGK1

- NUOB_BRUME

UniProt

Q8YGK1 - NUOB_BRUME

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Protein

NADH-quinone oxidoreductase subunit B

Gene
nuoB, BMEI1157
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi73 – 731Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi137 – 1371Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi167 – 1671Iron-sulfur (4Fe-4S) Reviewed prediction

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. iron ion binding Source: UniProtKB-HAMAP
  3. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  4. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit B (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit B
NDH-1 subunit B
Gene namesi
Name:nuoB
Ordered Locus Names:BMEI1157
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193NADH-quinone oxidoreductase subunit BUniRule annotationPRO_0000358359Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Protein-protein interaction databases

STRINGi224914.BMEI1157.

Structurei

3D structure databases

ProteinModelPortaliQ8YGK1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228249.
KOiK00331.
OrthoDBiEOG62K20C.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YGK1-1 [UniParc]FASTAAdd to Basket

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MGLTGTNTTL VAPQPKGILD PRTGKPVGSD DAFFNDLNGE LSDKGFIVTS    50
ADALITWART GSLMWMTFGL ACCAVEMMHI SMPRYDAERF GIAPRASPRQ 100
SDVMIVAGTL TNKMAPALRK VYDQMPEPRY VISMGSCANG GGYYHYSYSV 150
VRGCDRVVPV DIYVPGCPPT AEALLYGILL LQKKIRRTGT IER 193
Length:193
Mass (Da):21,032
Last modified:December 16, 2008 - v2
Checksum:i07E2DF39F0E5DF32
GO

Sequence cautioni

The sequence AAL52338.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52338.1. Different initiation.
PIRiAG3396.
RefSeqiNP_540074.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52338; AAL52338; BMEI1157.
GeneIDi1196868.
KEGGibme:BMEI1157.
PATRICi17797704. VBIBruMel146950_0667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52338.1 . Different initiation.
PIRi AG3396.
RefSeqi NP_540074.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YGK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52338 ; AAL52338 ; BMEI1157 .
GeneIDi 1196868.
KEGGi bme:BMEI1157.
PATRICi 17797704. VBIBruMel146950_0667.

Phylogenomic databases

HOGENOMi HOG000228249.
KOi K00331.
OrthoDBi EOG62K20C.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiNUOB_BRUME
AccessioniPrimary (citable) accession number: Q8YGK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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