Q8YGI8 (ARGC_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BMEI1171

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_0000112504
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YGI8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 022CE77DE4957994	FASTA	310	33,827
	10 20 30 40 50 60 MKPKIFIDGE HGTTGLQIRT RLAERDDLEV ISIPEAERRN KDLRADYLRA ADIAILCLPD 70 80 90 100 110 120 DASKEAVSLL EGHNSTRIID TSTTHRVHPD WAYGFAELAK GQRERIAEAR LVANPGCYPT 130 140 150 160 170 180 GAIALVRPLR DAGLLPADYP VSVNAVSGYT GGGKQLIAQM EDRNHPDYLA ANNFLYGLPL 190 200 210 220 230 240 KHKHVPELQL HGRLDRRPIF SPSVGRFPQG MIVQVPLFLS ELEGSPSLAK VHAVLTEHYA 250 260 270 280 290 300 GQDIVEVVPL EESAKLPRVD AEELAGKDGM KLFVFGTEDH GQVNLVALLD NLGKGASGAA 310 VQNMNLMLGK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52352.1.
PIR	AE3398.
RefSeq	NP_540088.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q8YGI8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1196882.
GenomeReviews	Gene locus BMEI1171 in contig AE008917_GR.
KEGG	bme:BMEI1171.
NMPDR	fig|224914.1.peg.1170.
PATRIC	17797672. VBIBruMel146950_0653.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	PIFVPSV.
PhylomeDB	Q8YGI8.
ProtClustDB	PRK11863.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI1171-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR023013. AGPR_AS. IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BRUME

Accession

Primary (citable) accession number: Q8YGI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program