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Q8YGA4

- NDK_BRUME

UniProt

Q8YGA4 - NDK_BRUME

Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Mar 2002)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATPUniRule annotation
    Binding sitei59 – 591ATPUniRule annotation
    Binding sitei87 – 871ATPUniRule annotation
    Binding sitei93 – 931ATPUniRule annotation
    Binding sitei104 – 1041ATPUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Active sitei117 – 1171Pros-phosphohistidine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CTP biosynthetic process Source: UniProtKB-HAMAP
    2. GTP biosynthetic process Source: UniProtKB-HAMAP
    3. UTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
    Short name:
    NDKUniRule annotation
    Short name:
    NDP kinaseUniRule annotation
    Alternative name(s):
    Nucleoside-2-P kinaseUniRule annotation
    Gene namesi
    Name:ndkUniRule annotation
    Ordered Locus Names:BMEI1256
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Nucleoside diphosphate kinasePRO_0000136956Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI1256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YGA4.
    SMRiQ8YGA4. Positions 2-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000224565.
    KOiK00940.
    OMAiKRIHMTR.
    OrthoDBiEOG67DPRV.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    HAMAPiMF_00451. NDP_kinase.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YGA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIERTFSMI KPDATRRNLT GAIIAKLEEA GLRVVASKRV WMSRREAEGF    50
    YAVHKDRPFF GELVEFMSSG PTVVQVLEGE NAIAKNREVM GATNPANADE 100
    GTIRKAFALS IGENSVHGSD APETAAEEIA YWFSGTEIVG 140
    Length:140
    Mass (Da):15,248
    Last modified:March 5, 2002 - v1
    Checksum:i847A873B5894ACBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52437.1.
    PIRiAB3409.
    RefSeqiNP_540173.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52437; AAL52437; BMEI1256.
    GeneIDi1196967.
    KEGGibme:BMEI1256.
    PATRICi17797463. VBIBruMel146950_0550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52437.1 .
    PIRi AB3409.
    RefSeqi NP_540173.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YGA4.
    SMRi Q8YGA4. Positions 2-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52437 ; AAL52437 ; BMEI1256 .
    GeneIDi 1196967.
    KEGGi bme:BMEI1256.
    PATRICi 17797463. VBIBruMel146950_0550.

    Phylogenomic databases

    HOGENOMi HOG000224565.
    KOi K00940.
    OMAi KRIHMTR.
    OrthoDBi EOG67DPRV.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    HAMAPi MF_00451. NDP_kinase.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiNDK_BRUME
    AccessioniPrimary (citable) accession number: Q8YGA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: March 5, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3