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Q8YGA4 (NDK_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoside diphosphate kinase

Short name=NDK
Short name=NDP kinase
EC=2.7.4.6
Alternative name(s):
Nucleoside-2-P kinase
Gene names
Name:ndk
Ordered Locus Names:BMEI1256
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. HAMAP-Rule MF_00451

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_00451

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00451

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00451

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00451.

Sequence similarities

Belongs to the NDK family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processCTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

UTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside diphosphate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Nucleoside diphosphate kinase HAMAP-Rule MF_00451
PRO_0000136956

Sites

Active site1171Pros-phosphohistidine intermediate By similarity
Binding site111ATP By similarity
Binding site591ATP By similarity
Binding site871ATP By similarity
Binding site931ATP By similarity
Binding site1041ATP By similarity
Binding site1141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YGA4 [UniParc].

Last modified March 5, 2002. Version 1.
Checksum: 847A873B5894ACBA

FASTA14015,248
        10         20         30         40         50         60 
MAIERTFSMI KPDATRRNLT GAIIAKLEEA GLRVVASKRV WMSRREAEGF YAVHKDRPFF 

        70         80         90        100        110        120 
GELVEFMSSG PTVVQVLEGE NAIAKNREVM GATNPANADE GTIRKAFALS IGENSVHGSD 

       130        140 
APETAAEEIA YWFSGTEIVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52437.1.
PIRAB3409.
RefSeqNP_540173.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YGA4.
SMRQ8YGA4. Positions 2-138.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52437; AAL52437; BMEI1256.
GeneID1196967.
KEGGbme:BMEI1256.
PATRIC17797463. VBIBruMel146950_0550.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000224565.
KOK00940.
OMAAEHSERP.
OrthoDBEOG67DPRV.
ProtClustDBPRK00668.

Family and domain databases

Gene3D3.30.70.141. 1 hit.
HAMAPMF_00451. NDP_kinase.
InterProIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMSSF54919. SSF54919. 1 hit.
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDK_BRUME
AccessionPrimary (citable) accession number: Q8YGA4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names