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Q8YG35 (GLNE_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-ammonia-ligase adenylyltransferase

EC=2.7.7.42
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name=ATase
[Glutamate--ammonia-ligase] adenylyltransferase
Gene names
Name:glnE
Ordered Locus Names:BMEI1327
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length983 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adenylation and deadenylation of glutamate--ammonia ligase By similarity. HAMAP-Rule MF_00802

Catalytic activity

ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. HAMAP-Rule MF_00802

Sequence similarities

Belongs to the GlnE family.

Sequence caution

The sequence AAL52508.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

[glutamate-ammonia-ligase] adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 983983Glutamate-ammonia-ligase adenylyltransferase HAMAP-Rule MF_00802
PRO_0000209235

Regions

Region117 – 328212GlnE 1 HAMAP-Rule MF_00802
Region631 – 847217GlnE 2 HAMAP-Rule MF_00802

Sequences

Sequence LengthMass (Da)Tools
Q8YG35 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 012BD3A12F7F2A9D

FASTA983109,444
        10         20         30         40         50         60 
MTVENAKALF FERNLCALTP LDPERASAFL ADLEARAREE ELAGVVALLG RKKAADFLSA 

        70         80         90        100        110        120 
ILDLSPFIRE ALTRQPRILD RIVSATPESA LEAILDEISA SGTVAGVSES ELMTSLRQLK 

       130        140        150        160        170        180 
REAHVLIALC DLARIFNTET TTDRLTDLAE ACTGAAVRFL LLDADAAGRI NLPDRSNPEK 

       190        200        210        220        230        240 
DCGWIVLGMG KFGARELNYS SDIDLIVFID ETKPAIGDPY ECVDTFSRLT RRLVRILQDR 

       250        260        270        280        290        300 
TGDGYVFRVD LRLRPDPGST PLAIPVGAAL HYYEGRGQNW ERAAMIKARP VAGDRLSGKQ 

       310        320        330        340        350        360 
ILAELSPYVW RKYLDYAAIA DVHSIKRQIH AHKGHGDIAV RGHNVKLGRG GIREIEFFVQ 

       370        380        390        400        410        420 
TQQLIAGGRF PELRGNQTVP MLARLAERGW ITQQARDALA QEYWFLRDVE HRIQMIADEQ 

       430        440        450        460        470        480 
THILPEDDEG FARVSHMMGY ADPAEFSEIF LAALKVVEKQ YAALFEQAPE LGAASGNLVF 

       490        500        510        520        530        540 
TGDVDDPGTL ETLSAMGYER SSDICRVIRT WHFGRYRATQ SAEARERLTE LTPALLKAFA 

       550        560        570        580        590        600 
ETRRADESLL RFDGFLQGLP AGIQLFSLLQ SNPRLLNLLV MIMSAAPRLA DIITRNPHVF 

       610        620        630        640        650        660 
DGLLDPAIFS EVPTRAYLEE RLRAFLGSAT DFEEVLDRLR IFAAEHRFLI GIRLLTGAIN 

       670        680        690        700        710        720 
GVRAGQAFSD LAELMVGRAL EAVEAELQRR HGKVKGAKVA LLAMGKLGSR ELTAGSDVDL 

       730        740        750        760        770        780 
ILLYDHDKDA EESDGEKPLA PSKYYIRLTQ RLIAALSAPT AEGVLYEVDM RLRPSGNKGP 

       790        800        810        820        830        840 
VATHIEAFGK YQRNDAWTWE HMALTRARPI HGDEAFIARI KVDIEDVLAM PRDVRKLAGD 

       850        860        870        880        890        900 
VREMRELIAQ EKPPRDDWDL KLKPGGIIDL EFIAQFATLA GYVKKTPRPF ATEEVLANLD 

       910        920        930        940        950        960 
PFFADPAMVD GLVEAHRFYT NLSQAIRLCL NDSAGLDQFP PGMRELLCRV AGLPDIERIE 

       970        980 
YELLEHYRLV RAAFDKLVGH GAD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52508.1. Different initiation.
PIRAI3417.
RefSeqNP_540244.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YG35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1327.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52508; AAL52508; BMEI1327.
GeneID1197038.
KEGGbme:BMEI1327.
PATRIC17852996. VBIBruMel92729_1488.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000256492.
KOK00982.
OMADAWTWEH.
OrthoDBEOG651SRZ.
ProtClustDBPRK14108.

Enzyme and pathway databases

BioCycBMEL224914:GCJ0-1368-MONOMER.

Family and domain databases

HAMAPMF_00802. GlnE.
InterProIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNE_BRUME
AccessionPrimary (citable) accession number: Q8YG35
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names