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Protein

Probable periplasmic serine endoprotease DegP-like

Gene

htrA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.By similarity

Catalytic activityi

Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Charge relay systemSequence analysis1
Active sitei182Charge relay systemSequence analysis1
Active sitei257Charge relay systemSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Probable periplasmic serine endoprotease DegP-like (EC:3.4.21.107)
Alternative name(s):
Protease Do
Gene namesi
Name:htrA
Ordered Locus Names:BMEI1330
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

Q8YG32:

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002692426 – 513Probable periplasmic serine endoprotease DegP-likeAdd BLAST488

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0883.

Structurei

3D structure databases

ProteinModelPortaliQ8YG32.
SMRiQ8YG32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 391PDZ 1PROSITE-ProRule annotationAdd BLAST92
Domaini414 – 500PDZ 2PROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 299Serine proteaseAdd BLAST175
Regioni255 – 257Substrate bindingBy similarity3
Regioni312 – 316Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223640.
KOiK04771.
OMAiDQLPDQH.

Family and domain databases

InterProiView protein in InterPro
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR011782. Pept_S1C_Do.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
PfamiView protein in Pfam
PF13180. PDZ_2. 2 hits.
PRINTSiPR00834. PROTEASES2C.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50494. SSF50494. 1 hit.
TIGRFAMsiTIGR02037. degP_htrA_DO. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8YG32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRARISNYR KGVAAVALSA ALAGAFVVTG PLGALNEARA EAVHVTPPQQ
60 70 80 90 100
AGFADLVEKV RPAVVSVRVK KDVQETSNRG PQFFGPPGFD QLPDGHPLKR
110 120 130 140 150
FFRDFGMEPR GDSRSDNRRG KANKPRPGHE RPVAQGSGFV ISEDGYVVTN
160 170 180 190 200
NHVVSDGDAY TVVLDDGTEL DAKLIGADPR TDLAVLKINA PKRKFVYVAF
210 220 230 240 250
GDDNKVRVGD WVVAVGNPFG LGGTVTSGIV SARGRDIGAG PYDDFIQIDA
260 270 280 290 300
AVNKGNSGGP AFDLSGEVIG INTAIFSPSG GSVGIAFAIP SSTAKQVVDQ
310 320 330 340 350
LIKKGSVERG WIGVQIQPVT KDIAASLGLA EEKGAIVASP QDDGPAAKAG
360 370 380 390 400
IKAGDVITAV NGETVQDPRD LARKVANIAP GEKAALTVWR KNKAEEINVT
410 420 430 440 450
IAAMPNDKGK SGSQSNDNDG GQGETLDSYG LTVVPSEDGK GVVVTDVDPD
460 470 480 490 500
SDAADRGIRS GDVIVSVNNQ TVKTAGDINK AITAAEKSGR KAVLLQLQSN
510
DQSRFVALPI NQE
Length:513
Mass (Da):53,514
Last modified:March 1, 2002 - v1
Checksum:iC472FEF99DFC6268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52511.1.
PIRiAD3418.
RefSeqiWP_004683321.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52511; AAL52511; BMEI1330.
GeneIDi29594176.
KEGGibme:BMEI1330.
bmel:DK63_73.
PATRICifig|224914.52.peg.76.

Similar proteinsi

Entry informationi

Entry nameiDEGPL_BRUME
AccessioniPrimary (citable) accession number: Q8YG32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families