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Q8YFY2

- BETA_BRUME

UniProt

Q8YFY2 - BETA_BRUME

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, BMEI1380
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1421-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:BMEI1380
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205584Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1380.

Structurei

3D structure databases

ProteinModelPortaliQ8YFY2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000139600.
KOiK00108.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YFY2-1 [UniParc]FASTAAdd to Basket

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MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS    50
FPMNMETYDW GFSSEPEPHI RGRSLVTPRG KVLGGSSSIN GMVYVRGHAC 100
DFDHWSQSGA RGWAYADVLP YFKRMENSQG GQEGWRGTNG PLYVQRGKRD 150
NPLFHAFVEA GHQAGFEVTD DYNGEKQEGF GPMEQTIHNG RRWSAANAYL 200
KPALKRPNVK LVKGFARKIV LEGKRAVGVE IEAGRTFSTI RARREVIIAA 250
SSINSPKLLM LSGIGPAAHL KEHGIDLVAD RPGVGQNLQD HLEVYIQQEC 300
TQPITLYSKL NLFSKARIGV EWLLFKTGDG ATNHFESAAF VRSKAGVEYP 350
DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP 400
VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFDPYRGAEI QPGAHVQTDD 450
EIDNFIREHV ESAFHPCGTC KMGAVDDPMA VVDPECRVIG VEGLRVADSS 500
IFPRITNGNL NGPSIMVGEK ASGHILGRTP LARSNQEPWI NPRWQVSDR 549
Length:549
Mass (Da):60,665
Last modified:February 16, 2004 - v2
Checksum:iFBB2B0956C20252B
GO

Sequence cautioni

The sequence AAL52561.1 differs from that shown. Reason: Frameshift at position 426.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52561.1. Frameshift.
PIRiAF3424.
RefSeqiNP_540297.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52561; AAL52561; BMEI1380.
GeneIDi1197091.
KEGGibme:BMEI1380.
PATRICi17853108. VBIBruMel92729_1544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52561.1 . Frameshift.
PIRi AF3424.
RefSeqi NP_540297.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFY2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52561 ; AAL52561 ; BMEI1380 .
GeneIDi 1197091.
KEGGi bme:BMEI1380.
PATRICi 17853108. VBIBruMel92729_1544.

Phylogenomic databases

HOGENOMi HOG000139600.
KOi K00108.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BMEL224914:GCJ0-1421-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiBETA_BRUME
AccessioniPrimary (citable) accession number: Q8YFY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: September 3, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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