Q8YFY0 (BETB_BRUME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Betaine aldehyde dehydrogenase Short name=BADH EC=1.2.1.8 | ||||
| Gene names |
| ||||
| Organism | Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 224914 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 487 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804 |
| Pathway | Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
| Sequence caution | The sequence AAL52563.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | betaine biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 487 | 487 | Betaine aldehyde dehydrogenase HAMAP MF_00804 | PRO_0000056537 | |||||
Regions | |||||||||
| Nucleotide binding | 227 – 232 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 249 | 1 | By similarity | ||||||
| Active site | 283 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. Overbeek R.Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008917 Genomic DNA. Translation: AAL52563.1. Different initiation. |
| PIR | AH3424. |
| RefSeq | NP_540299.2. NC_003317.1. |
3D structure databases | |
| ProteinModelPortal | Q8YFY0. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1197093. |
| GenomeReviews | Gene locus BMEI1382 in contig AE008917_GR. |
| KEGG | bme:BMEI1382. |
| PATRIC | 17853110. VBIBruMel92729_1545. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG752218. |
| OMA | IMRERNR. |
| PhylomeDB | Q8YFY0. |
| ProtClustDB | PRK13252. |
Enzyme and pathway databases | |
| BioCyc | BMEL224914:BMEI1382-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00804. BADH. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR011264. Betaine_Ald_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| KO | K00130. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01804. BADH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BETB_BRUME | ||||||||
| Accession | Primary (citable) accession number: Q8YFY0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella melitensis Brucella melitensis (strain 16M): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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