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Q8YFY0

- BETB_BRUME

UniProt

Q8YFY0 - BETB_BRUME

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, BMEI1382
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei161 – 1611Charge relay system By similarity
Binding sitei208 – 2081NAD/NADP; via amide nitrogen By similarity
Metal bindingi243 – 2431Potassium 2; via carbonyl oxygen By similarity
Active sitei249 – 2491Proton acceptor By similarity
Binding sitei283 – 2831NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1524NAD/NADP By similarity
Nucleotide bindingi175 – 1784NAD/NADP By similarity
Nucleotide bindingi227 – 2326NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:BMEI1382
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_0000056537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI1382.

Structurei

3D structure databases

ProteinModelPortaliQ8YFY0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000271505.
KOiK00130.
OMAiISREHAN.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YFY0-1 [UniParc]FASTAAdd to Basket

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MKAQPKASHF IGGAFVEDKA GKPLPVIYPA TGEEIASLYS ATPGIIEAAY    50
AAALKAQGEW AALKPVERGR ILRRTAEILR EKNRKLSKLE TLDTGKALQE 100
TLVADAASAA DALEFFGGII SGFNGEFVEL GGSFAYTRRE ALGICVGIGA 150
WNYPIQIAAW KSAPALAMGN AFIFKPSENT PLSALALAEA YKEAGLPDGL 200
FNVVQGYGDV GAALVNHRLT AKVSLTGSVP TGRRIMAQAG EQLKHVTMEL 250
GGKSPLIVFD DADLESAIGG AMLGNFYSTG QVCSNGTRVF VHKNIRERFI 300
ERLVERTRKI RIGDPFDEAT QMGPLISAAQ RDKVLSYIKK GKAEGATLAC 350
GGGVPKLQGF DKGFFIEPTV FADVTDTMTI AREEIFGPVM SVLEFSDEDE 400
VIARANDSEF GLAAGVFTAD LSRGHHVIGQ IKAGTCWINA YNLTPVEVPF 450
GGYKQSGIGR ENGIAALAHY SQIKTVYVEM GKVDSPY 487
Length:487
Mass (Da):52,035
Last modified:February 1, 2005 - v2
Checksum:iE4B8F2DFC983A654
GO

Sequence cautioni

The sequence AAL52563.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52563.1. Different initiation.
PIRiAH3424.
RefSeqiNP_540299.2. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52563; AAL52563; BMEI1382.
GeneIDi1197093.
KEGGibme:BMEI1382.
PATRICi17853110. VBIBruMel92729_1545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52563.1 . Different initiation.
PIRi AH3424.
RefSeqi NP_540299.2. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52563 ; AAL52563 ; BMEI1382 .
GeneIDi 1197093.
KEGGi bme:BMEI1382.
PATRICi 17853110. VBIBruMel92729_1545.

Phylogenomic databases

HOGENOMi HOG000271505.
KOi K00130.
OMAi ISREHAN.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiBETB_BRUME
AccessioniPrimary (citable) accession number: Q8YFY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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