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Q8YFX5 (XYLA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylose isomerase

EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:BMEI1387
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylopyranose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_00455

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00455

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Xylose isomerase HAMAP-Rule MF_00455
PRO_0000195771

Sites

Active site1001 By similarity
Active site1031 By similarity
Metal binding2311Magnesium 1 By similarity
Metal binding2671Magnesium 1 By similarity
Metal binding2671Magnesium 2 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2951Magnesium 1 By similarity
Metal binding3061Magnesium 2 By similarity
Metal binding3081Magnesium 2 By similarity
Metal binding3381Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YFX5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 5C5A95ECE415E6E2

FASTA43549,004
        10         20         30         40         50         60 
MSTGFFGDIQ KVRYEGPESD NPLAFRHYNA DEIVLGKRME DHLRFAVAYW HSFAWEGGDP 

        70         80         90        100        110        120 
FGGRTFDRPW FSNEIDAAKL KADVAFEFFS LLGAPYYCFH DADVRPEGRN FAENTRYLNE 

       130        140        150        160        170        180 
IVDIFEKKQA ETGMKLLWGT ANLFSNRRYM AGAATNPDPD VFAFAAATVK TCIDATKRLG 

       190        200        210        220        230        240 
GENYVLWGGR EGYETLLNTD LSRELDHMGR FLSLVVEYKH KIGFKGTILI EPKPQEPTKH 

       250        260        270        280        290        300 
QYDYDVATVY GFLKRYGLEN EVKVNIEQGH AILAGHSFEH ELALARTLGI FGSIDMNRND 

       310        320        330        340        350        360 
YQSGWDTDQF PNNVPEMALA YYQVLLAGGF TTGGTNFDAK LRRQSLDPQD LLIGHIGGMD 

       370        380        390        400        410        420 
CCARGLKAAA RMLEDGALSK PLDERYAGWN GEFGKRLLSG LSLDQIAGEV EAKDINPQPK 

       430 
SGRQEYLENI VNRYV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52568.1.
PIRAE3425.
RefSeqNP_540304.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YFX5.
SMRQ8YFX5. Positions 4-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52568; AAL52568; BMEI1387.
GeneID1197098.
KEGGbme:BMEI1387.
PATRIC17797177. VBIBruMel146950_0406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000252293.
KOK01805.
OMAKADSAFE.
OrthoDBEOG62NX4R.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_BRUME
AccessionPrimary (citable) accession number: Q8YFX5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names