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Q8YFX5

- XYLA_BRUME

UniProt

Q8YFX5 - XYLA_BRUME

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Protein

Xylose isomerase

Gene
xylA, BMEI1387
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001 By similarity
Active sitei103 – 1031 By similarity
Metal bindingi231 – 2311Magnesium 1 By similarity
Metal bindingi267 – 2671Magnesium 1 By similarity
Metal bindingi267 – 2671Magnesium 2 By similarity
Metal bindingi270 – 2701Magnesium 2 By similarity
Metal bindingi295 – 2951Magnesium 1 By similarity
Metal bindingi306 – 3061Magnesium 2 By similarity
Metal bindingi308 – 3081Magnesium 2 By similarity
Metal bindingi338 – 3381Magnesium 1 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BMEI1387
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Xylose isomeraseUniRule annotationPRO_0000195771Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI1387.

Structurei

3D structure databases

ProteinModelPortaliQ8YFX5.
SMRiQ8YFX5. Positions 4-435.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiKADSAFE.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YFX5-1 [UniParc]FASTAAdd to Basket

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MSTGFFGDIQ KVRYEGPESD NPLAFRHYNA DEIVLGKRME DHLRFAVAYW    50
HSFAWEGGDP FGGRTFDRPW FSNEIDAAKL KADVAFEFFS LLGAPYYCFH 100
DADVRPEGRN FAENTRYLNE IVDIFEKKQA ETGMKLLWGT ANLFSNRRYM 150
AGAATNPDPD VFAFAAATVK TCIDATKRLG GENYVLWGGR EGYETLLNTD 200
LSRELDHMGR FLSLVVEYKH KIGFKGTILI EPKPQEPTKH QYDYDVATVY 250
GFLKRYGLEN EVKVNIEQGH AILAGHSFEH ELALARTLGI FGSIDMNRND 300
YQSGWDTDQF PNNVPEMALA YYQVLLAGGF TTGGTNFDAK LRRQSLDPQD 350
LLIGHIGGMD CCARGLKAAA RMLEDGALSK PLDERYAGWN GEFGKRLLSG 400
LSLDQIAGEV EAKDINPQPK SGRQEYLENI VNRYV 435
Length:435
Mass (Da):49,004
Last modified:March 1, 2002 - v1
Checksum:i5C5A95ECE415E6E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52568.1.
PIRiAE3425.
RefSeqiNP_540304.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52568; AAL52568; BMEI1387.
GeneIDi1197098.
KEGGibme:BMEI1387.
PATRICi17797177. VBIBruMel146950_0406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52568.1 .
PIRi AE3425.
RefSeqi NP_540304.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFX5.
SMRi Q8YFX5. Positions 4-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52568 ; AAL52568 ; BMEI1387 .
GeneIDi 1197098.
KEGGi bme:BMEI1387.
PATRICi 17797177. VBIBruMel146950_0406.

Phylogenomic databases

HOGENOMi HOG000252293.
KOi K01805.
OMAi KADSAFE.
OrthoDBi EOG62NX4R.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiXYLA_BRUME
AccessioniPrimary (citable) accession number: Q8YFX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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