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Q8YFX5

- XYLA_BRUME

UniProt

Q8YFX5 - XYLA_BRUME

Protein

Xylose isomerase

Gene

xylA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001UniRule annotation
    Active sitei103 – 1031UniRule annotation
    Metal bindingi231 – 2311Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 2UniRule annotation
    Metal bindingi270 – 2701Magnesium 2UniRule annotation
    Metal bindingi295 – 2951Magnesium 1UniRule annotation
    Metal bindingi306 – 3061Magnesium 2UniRule annotation
    Metal bindingi308 – 3081Magnesium 2UniRule annotation
    Metal bindingi338 – 3381Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:BMEI1387
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Xylose isomerasePRO_0000195771Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI1387.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YFX5.
    SMRiQ8YFX5. Positions 4-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252293.
    KOiK01805.
    OMAiKADSAFE.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YFX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGFFGDIQ KVRYEGPESD NPLAFRHYNA DEIVLGKRME DHLRFAVAYW    50
    HSFAWEGGDP FGGRTFDRPW FSNEIDAAKL KADVAFEFFS LLGAPYYCFH 100
    DADVRPEGRN FAENTRYLNE IVDIFEKKQA ETGMKLLWGT ANLFSNRRYM 150
    AGAATNPDPD VFAFAAATVK TCIDATKRLG GENYVLWGGR EGYETLLNTD 200
    LSRELDHMGR FLSLVVEYKH KIGFKGTILI EPKPQEPTKH QYDYDVATVY 250
    GFLKRYGLEN EVKVNIEQGH AILAGHSFEH ELALARTLGI FGSIDMNRND 300
    YQSGWDTDQF PNNVPEMALA YYQVLLAGGF TTGGTNFDAK LRRQSLDPQD 350
    LLIGHIGGMD CCARGLKAAA RMLEDGALSK PLDERYAGWN GEFGKRLLSG 400
    LSLDQIAGEV EAKDINPQPK SGRQEYLENI VNRYV 435
    Length:435
    Mass (Da):49,004
    Last modified:March 1, 2002 - v1
    Checksum:i5C5A95ECE415E6E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52568.1.
    PIRiAE3425.
    RefSeqiNP_540304.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52568; AAL52568; BMEI1387.
    GeneIDi1197098.
    KEGGibme:BMEI1387.
    PATRICi17797177. VBIBruMel146950_0406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52568.1 .
    PIRi AE3425.
    RefSeqi NP_540304.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YFX5.
    SMRi Q8YFX5. Positions 4-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1387.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52568 ; AAL52568 ; BMEI1387 .
    GeneIDi 1197098.
    KEGGi bme:BMEI1387.
    PATRICi 17797177. VBIBruMel146950_0406.

    Phylogenomic databases

    HOGENOMi HOG000252293.
    KOi K01805.
    OMAi KADSAFE.
    OrthoDBi EOG62NX4R.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiXYLA_BRUME
    AccessioniPrimary (citable) accession number: Q8YFX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3