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Q8YFU1

- HIUH_BRUME

UniProt

Q8YFU1 - HIUH_BRUME

Protein

5-hydroxyisourate hydrolase

Gene

BMEI1429

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

    Catalytic activityi

    5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71SubstrateBy similarity
    Binding sitei46 – 461SubstrateBy similarity
    Binding sitei115 – 1151SubstrateBy similarity

    GO - Molecular functioni

    1. hydroxyisourate hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. transport Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-1471-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxyisourate hydrolase (EC:3.5.2.17)
    Short name:
    HIU hydrolase
    Short name:
    HIUHase
    Gene namesi
    Ordered Locus Names:BMEI1429
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1181185-hydroxyisourate hydrolasePRO_0000050609Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224914.BMEI1429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YFU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000251776.
    KOiK07127.
    OMAiYRHYSIA.
    OrthoDBiEOG6038XF.

    Family and domain databases

    Gene3Di2.60.40.180. 1 hit.
    InterProiIPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view]
    PfamiPF00576. Transthyretin. 1 hit.
    [Graphical view]
    PRINTSiPR00189. TRNSTHYRETIN.
    SUPFAMiSSF49472. SSF49472. 1 hit.
    TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
    PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YFU1-1 [UniParc]FASTAAdd to Basket

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    MGKLSTHVLD TAHGTPAAAM RVELYRIAAS GTPELLKRVV TNLDGRTDAP    50
    LLSGDEMRTG IYELQFHVAE YFEGRGAELA HEPFLDLIPI RFGIADEDGN 100
    YHVPLLVSPW SYSTYRGS 118
    Length:118
    Mass (Da):13,033
    Last modified:November 7, 2003 - v2
    Checksum:i78CF15B3E0178A8B
    GO

    Sequence cautioni

    The sequence AAL52610.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52610.1. Different initiation.
    PIRiAG3430.
    RefSeqiNP_540346.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52610; AAL52610; BMEI1429.
    GeneIDi1197140.
    KEGGibme:BMEI1429.
    PATRICi17853210. VBIBruMel92729_1594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52610.1 . Different initiation.
    PIRi AG3430.
    RefSeqi NP_540346.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YFU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52610 ; AAL52610 ; BMEI1429 .
    GeneIDi 1197140.
    KEGGi bme:BMEI1429.
    PATRICi 17853210. VBIBruMel92729_1594.

    Phylogenomic databases

    HOGENOMi HOG000251776.
    KOi K07127.
    OMAi YRHYSIA.
    OrthoDBi EOG6038XF.

    Enzyme and pathway databases

    BioCyci BMEL224914:GCJ0-1471-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.180. 1 hit.
    InterProi IPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view ]
    Pfami PF00576. Transthyretin. 1 hit.
    [Graphical view ]
    PRINTSi PR00189. TRNSTHYRETIN.
    SUPFAMi SSF49472. SSF49472. 1 hit.
    TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
    PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiHIUH_BRUME
    AccessioniPrimary (citable) accession number: Q8YFU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    HIU hydrolysis also occurs spontaneously, but more slowly.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3