Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8YFU1

- HIUH_BRUME

UniProt

Q8YFU1 - HIUH_BRUME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-hydroxyisourate hydrolase

Gene

BMEI1429

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71SubstrateBy similarity
Binding sitei46 – 461SubstrateBy similarity
Binding sitei115 – 1151SubstrateBy similarity

GO - Molecular functioni

  1. hydroxyisourate hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1471-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolase (EC:3.5.2.17)
Short name:
HIU hydrolase
Short name:
HIUHase
Gene namesi
Ordered Locus Names:BMEI1429
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1181185-hydroxyisourate hydrolasePRO_0000050609Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224914.BMEI1429.

Structurei

3D structure databases

ProteinModelPortaliQ8YFU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000251776.
KOiK07127.
OMAiYRHYSIA.
OrthoDBiEOG6038XF.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YFU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKLSTHVLD TAHGTPAAAM RVELYRIAAS GTPELLKRVV TNLDGRTDAP
60 70 80 90 100
LLSGDEMRTG IYELQFHVAE YFEGRGAELA HEPFLDLIPI RFGIADEDGN
110
YHVPLLVSPW SYSTYRGS
Length:118
Mass (Da):13,033
Last modified:November 7, 2003 - v2
Checksum:i78CF15B3E0178A8B
GO

Sequence cautioni

The sequence AAL52610.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52610.1. Different initiation.
PIRiAG3430.
RefSeqiNP_540346.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52610; AAL52610; BMEI1429.
GeneIDi1197140.
KEGGibme:BMEI1429.
PATRICi17853210. VBIBruMel92729_1594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52610.1 . Different initiation.
PIRi AG3430.
RefSeqi NP_540346.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52610 ; AAL52610 ; BMEI1429 .
GeneIDi 1197140.
KEGGi bme:BMEI1429.
PATRICi 17853210. VBIBruMel92729_1594.

Phylogenomic databases

HOGENOMi HOG000251776.
KOi K07127.
OMAi YRHYSIA.
OrthoDBi EOG6038XF.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-1471-MONOMER.

Family and domain databases

Gene3Di 2.60.40.180. 1 hit.
InterProi IPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view ]
Pfami PF00576. Transthyretin. 1 hit.
[Graphical view ]
PRINTSi PR00189. TRNSTHYRETIN.
SUPFAMi SSF49472. SSF49472. 1 hit.
TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiHIUH_BRUME
AccessioniPrimary (citable) accession number: Q8YFU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 7, 2003
Last modified: October 1, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3