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Protein

5-hydroxyisourate hydrolase

Gene

BMEI1429

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7SubstrateBy similarity1
Binding sitei46SubstrateBy similarity1
Binding sitei115SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolase (EC:3.5.2.17)
Short name:
HIU hydrolase
Short name:
HIUHase
Gene namesi
Ordered Locus Names:BMEI1429
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506091 – 1185-hydroxyisourate hydrolaseAdd BLAST118

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224914.BAWG_0795

Structurei

3D structure databases

ProteinModelPortaliQ8YFU1
SMRiQ8YFU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105VT2 Bacteria
COG2351 LUCA
HOGENOMiHOG000251776
KOiK07127
OMAiMFRIDNG

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR014306 Hydroxyisourate_hydrolase
IPR023418 Thyroxine_BS
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SUPFAMiSSF49472 SSF49472, 1 hit
TIGRFAMsiTIGR02962 hdxy_isourate, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YFU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLSTHVLD TAHGTPAAAM RVELYRIAAS GTPELLKRVV TNLDGRTDAP
60 70 80 90 100
LLSGDEMRTG IYELQFHVAE YFEGRGAELA HEPFLDLIPI RFGIADEDGN
110
YHVPLLVSPW SYSTYRGS
Length:118
Mass (Da):13,033
Last modified:November 7, 2003 - v2
Checksum:i78CF15B3E0178A8B
GO

Sequence cautioni

The sequence AAL52610 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL52610.1 Different initiation.
PIRiAG3430
RefSeqiWP_002966708.1, NZ_GG703778.1

Genome annotation databases

EnsemblBacteriaiAAL52610; AAL52610; BMEI1429
GeneIDi29594271
KEGGibme:BMEI1429
bmel:DK63_2059
PATRICifig|224914.52.peg.2161

Similar proteinsi

Entry informationi

Entry nameiHIUH_BRUME
AccessioniPrimary (citable) accession number: Q8YFU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 7, 2003
Last modified: March 28, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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