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Protein

Ureidoglycolate lyase

Gene

allA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.UniRule annotation

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.UniRule annotation

Cofactori

Ni2+UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ureidoglycolate hydrolase activity Source: InterPro
  2. ureidoglycolate lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

UniPathwayiUPA00395.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyaseUniRule annotation (EC:4.3.2.3UniRule annotation)
Alternative name(s):
UreidoglycolataseUniRule annotation
Gene namesi
Name:allAUniRule annotation
Ordered Locus Names:BMEI1430
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Ureidoglycolate lyasePRO_0000120544Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI1430.

Structurei

3D structure databases

ProteinModelPortaliQ8YFU0.
SMRiQ8YFU0. Positions 4-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000256169.
KOiK01483.
OMAiNCDIFQF.
OrthoDBiEOG6JX7JB.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_hydro. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YFU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIETLTVEP LTKEAFAPFG DVIEVEGAQL RLINNGTTER YHDLARVEAA
60 70 80 90 100
GTQTRALINI FRGQSFAAPI DIMMMERHPF GSQAFIPLNG RPFLVVVAED
110 120 130 140 150
AGAGPARPRA FLARGDQGVN YLRNIWHHPL LALEQKSDFL VVDRAGREDN
160
LEEYFFSDYA YRIETTQTA
Length:169
Mass (Da):18,982
Last modified:March 1, 2002 - v1
Checksum:i491CF472902AE5AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52611.1.
PIRiAH3430.
RefSeqiNP_540347.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52611; AAL52611; BMEI1430.
KEGGibme:BMEI1430.
PATRICi17797105. VBIBruMel146950_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52611.1.
PIRiAH3430.
RefSeqiNP_540347.1. NC_003317.1.

3D structure databases

ProteinModelPortaliQ8YFU0.
SMRiQ8YFU0. Positions 4-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI1430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52611; AAL52611; BMEI1430.
KEGGibme:BMEI1430.
PATRICi17797105. VBIBruMel146950_0372.

Phylogenomic databases

HOGENOMiHOG000256169.
KOiK01483.
OMAiNCDIFQF.
OrthoDBiEOG6JX7JB.

Enzyme and pathway databases

UniPathwayiUPA00395.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
HAMAPiMF_00616. Ureidogly_lyase.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_lyase.
IPR023525. Ureidogly_lyase_bac.
IPR024060. Ureidoglycolate_lyase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_hydro. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiALLA_BRUME
AccessioniPrimary (citable) accession number: Q8YFU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.